HitPredict

Interactor 1: ISG15 (P05161)
Ubiquitin-like protein ISG15 (Interferon-induced 15 kDa protein) (Interferon-induced 17 kDa protein) (IP17) (Ubiquitin cross-reactive protein) (hUCRP)
Gene: ISG15

Interactor 2: IRF1 (P10914)
Interferon regulatory factor 1 (IRF-1)
Gene: IRF1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	8943426, 12654826
Identification Methods	electrophoretic mobility supershift assay
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0032728 - positive regulation of interferon-beta production GO:0051607 - defense response to virus
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 165 Hs			1 325
+	Hs
		397918 ISG15_HUMAN (1-165): 2.83e-48: 155: 100.00		IRF8_HUMAN (7-270): 1.22e-99: 301: 28.79
+	Mm
		618972 ISG15_MOUSE (1-160): 2.22e-48: 155: 63.75		IRF8_MOUSE (7-270): 2.81e-94: 287: 28.03
+	Hs
		397754 ISG15_HUMAN (1-165): 2.83e-48: 155: 100.00		IRF2_HUMAN (1-268): 2.01e-86: 265: 45.55
+	Hs
		475026 UBB_HUMAN (3-157): 6.34e-67: 205: 32.26		IRF3_HUMAN (1-263): 7.43e-62: 204: 21.29
+	Hs
		397967 ISG15_HUMAN (1-165): 2.83e-48: 155: 100.00		IRF3_HUMAN (1-263): 7.43e-62: 204: 21.29
+	Mm
		936898 ISG15_MOUSE (1-160): 2.22e-48: 155: 63.75		IRF3_MOUSE (1-260): 2.47e-59: 197: 25.19
+	Hs
		397915 ISG15_HUMAN (1-165): 2.83e-48: 155: 100.00		IRF9_HUMAN (7-267): 2.06e-56: 189: 26.02
+	Hs
		397980 ISG15_HUMAN (1-165): 2.83e-48: 155: 100.00		IRF4_HUMAN (7-207): 5.79e-56: 189: 27.36
+	Mm
		476725 UBC_MOUSE (2-110): 1.68e-33: 126: 28.44		IRF5_MOUSE (2-260): 3.08e-58: 196: 25.36
+	Hs
		398058 ISG15_HUMAN (1-165): 2.83e-48: 155: 100.00		IRF7_HUMAN (4-252): 9.35e-41: 150: 21.09