HitPredict

Interactor 1: ISG15 (P05161)
Ubiquitin-like protein ISG15 (Interferon-induced 15 kDa protein) (Interferon-induced 17 kDa protein) (IP17) (Ubiquitin cross-reactive protein) (hUCRP)
Gene: ISG15

Interactor 2: IRF4 (Q15306)
Interferon regulatory factor 4 (IRF-4) (Lymphocyte-specific interferon regulatory factor) (LSIRF) (Multiple myeloma oncogene 1) (NF-EM5)
Gene: IRF4

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	10714679, 12055236
Identification Methods	electrophoretic mobility supershift assay
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0032733 - positive regulation of interleukin-10 production
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 165 Hs			1 451
+	Hs
		475026 UBB_HUMAN (3-157): 6.34e-67: 205: 32.26		IRF3_HUMAN (23-438): 6.3e-150: 434: 27.74
+	Hs
		397918 ISG15_HUMAN (1-165): 2.83e-48: 155: 100.00		IRF8_HUMAN (20-423): 1.28e-156: 451: 43.61
+	Mm
		618972 ISG15_MOUSE (1-160): 2.22e-48: 155: 63.75		IRF8_MOUSE (20-423): 1.94e-154: 446: 43.10
+	Hs
		397967 ISG15_HUMAN (1-165): 2.83e-48: 155: 100.00		IRF3_HUMAN (23-438): 6.3e-150: 434: 27.74
+	Mm
		476725 UBC_MOUSE (2-110): 1.68e-33: 126: 28.44		IRF5_MOUSE (23-438): 8.13e-160: 462: 33.33
+	Mm
		936898 ISG15_MOUSE (1-160): 2.22e-48: 155: 63.75		IRF3_MOUSE (23-438): 1.12e-144: 421: 26.29
+	Hs
		397915 ISG15_HUMAN (1-165): 2.83e-48: 155: 100.00		IRF9_HUMAN (22-425): 1.05e-130: 384: 32.84
+	Hs
		398058 ISG15_HUMAN (1-165): 2.83e-48: 155: 100.00		IRF7_HUMAN (26-421): 3.09e-123: 369: 26.20
+	Hs
		397741 ISG15_HUMAN (1-165): 2.83e-48: 155: 100.00		IRF1_HUMAN (23-251): 1.27e-71: 230: 26.34
+	Hs
		397754 ISG15_HUMAN (1-165): 2.83e-48: 155: 100.00		IRF2_HUMAN (23-244): 1.07e-53: 184: 25.33