Interactor 1: IF2A (P05198)
Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha) (eIF2-alpha)
Gene: EIF2S1

Interactor 2: IF2G (P41091)
Eukaryotic translation initiation factor 2 subunit 3 (EC 3.6.5.3) (Eukaryotic translation initiation factor 2 subunit gamma X) (eIF2-gamma X) (eIF2gX)
Gene: EIF2S3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.93 1.00 0.965

The method score is based on:

Property Details
Experiments 35271311, 35031321, 30699057, 33961781, 35235311, 34349018, 37071682, 16288713
Identification Methods affinity chromatography technology, cross-linking study, enzyme linked immunosorbent assay, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains EIF_2_alpha~GTP_EFTU, EIF_2_alpha~GTP_EFTU_D2
Common GO terms GO:0003743 - translation initiation factor activity
GO:0005829 - cytosol
GO:0005850 - eukaryotic translation initiation factor 2 complex
GO:0006413 - translational initiation
GO:0070062 - extracellular exosome
Homologous interactions 9

Homologous interactions

Color coding for hit scores

1 315
Hs

1 472
+ Dm
+ Hs
+ Sc
+ Sc
+ Ss
+ Hv
+ Sc
+ Dm
+ Sc

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Last updated: 15 Jul 2024