HitPredict

Interactor 1: IL6 (P05231)
Interleukin-6 (IL-6) (B-cell stimulatory factor 2) (BSF-2) (CTL differentiation factor) (CDF) (Hybridoma growth factor) (Interferon beta-2) (IFN-beta-2)
Gene: IL6

Interactor 2: REL (Q04864)
Proto-oncogene c-Rel
Gene: REL

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	1372388, 19122653
Identification Methods	electrophoretic mobility supershift assay, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006954 - inflammatory response GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 212 Hs			1 619
+	Mm
		439911 IL6_MOUSE (1-211): 3.15e-121: 343: 41.04		TF65_MOUSE (2-576): 1.99e-167: 490: 38.89
+	Mm
		439903 IL6_MOUSE (1-211): 3.15e-121: 343: 41.04		NFKB1_MOUSE (1-414): 1.82e-152: 465: 33.56
+	Hs
		399174 IL6_HUMAN (1-212): 6.83e-114: 325: 100.00		TF65_HUMAN (2-576): 4.74e-158: 466: 37.89
+	Hs
		399170 IL6_HUMAN (1-212): 6.83e-114: 325: 100.00		NFKB1_HUMAN (1-375): 2e-145: 447: 37.47