HitPredict

Interactor 1: ICAM1 (P05362)
Intercellular adhesion molecule 1 (ICAM-1) (Major group rhinovirus receptor) (CD antigen CD54)
Gene: ICAM1

Interactor 2: ITAL (P20701)
Integrin alpha-L (CD11 antigen-like family member A) (Leukocyte adhesion glycoprotein LFA-1 alpha chain) (LFA-1A) (Leukocyte function-associated molecule 1 alpha chain) (CD antigen CD11a)
Gene: ITGAL

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.84 1.00 0.920

The method score is based on:

Property Details
Experiments 12526797, 29997244, 11279101, 11786177, 16595626
Identification Methods x-ray crystallography, fluorescent resonance energy transfer, pull down, surface plasmon resonance
Interaction Type association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains ICAM_N~VWA
Common GO terms GO:0002291 - T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
GO:0005178 - integrin binding
GO:0005886 - plasma membrane
GO:0007155 - cell adhesion
GO:0007157 - heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
and 6 others

more...
Homologous interactions 7

Homologous interactions

Color coding for hit scores

1 532
Hs

1 1170
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024