HitPredict

Interactor 1: JUN (P05412)
Transcription factor Jun (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (Transcription factor AP-1 subunit Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39)
Gene: JUN

Interactor 2: MK09 (P45984)
Mitogen-activated protein kinase 9 (MAP kinase 9) (MAPK 9) (EC 2.7.11.24) (JNK-55) (Stress-activated protein kinase 1a) (SAPK1a) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2)
Gene: MAPK9

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.98	0.60	0.767

Property	Details
Experiments	8001819, 9596579, 18940813, 15637069, 8945519, 17637567, 28753655, 8985011, 10490605, 16533805, 19527717, 8654373, 19910486, 17189706, 16824735, 17875713, 11278395, 12788955, 1922387
Identification Methods	pull down, enzymatic study, two hybrid, biochemical, in-gel kinase assay, protein kinase assay
Interaction Type	direct interaction, physical association, phosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0034614 - cellular response to reactive oxygen species GO:0071276 - cellular response to cadmium ion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 331 Hs			1 424
+	Rn
		567364 JUN_RAT (1-331): 3.98e-86: 264: 94.01		MK09_RAT (1-424): 4.52e-161: 462: 98.82
+	Hs
		401690 JUN_HUMAN (1-331): 8.11e-87: 266: 100.00		MK10_HUMAN (1-424): 1.16e-155: 449: 84.04
+	Rn
		567365 JUN_RAT (1-331): 3.98e-86: 264: 94.01		MK10_RAT (1-424): 1.63e-155: 449: 84.04
+	Hs
		401592 JUN_HUMAN (1-331): 8.11e-87: 266: 100.00		MK08_HUMAN (1-424): 1.17e-153: 443: 80.80
+	Rn
		567363 JUN_RAT (1-331): 3.98e-86: 264: 94.01		MK08_RAT (1-408): 3.58e-147: 426: 81.02
+	Mm
		404155 JUN_MOUSE (1-331): 5.76e-86: 263: 94.61		MK08_MOUSE (1-380): 8.38e-145: 419: 83.42
+	Hs
		566735 JUNB_HUMAN (1-331): 3.94e-63: 205: 43.89		MK09_HUMAN (1-424): 2.83e-163: 467: 100.00
+	Hs
		566734 JUNB_HUMAN (1-331): 3.94e-63: 205: 43.89		MK08_HUMAN (1-424): 1.17e-153: 443: 80.80
+	Hs
		402080 JUN_HUMAN (1-331): 8.11e-87: 266: 100.00		MK14_HUMAN (4-375): 9.3e-130: 379: 48.00
+	Hs
		568074 JUND_HUMAN (5-331): 5.93e-47: 163: 45.86		MK09_HUMAN (1-424): 2.83e-163: 467: 100.00
+	Hs
		568080 JUND_HUMAN (5-331): 5.93e-47: 163: 45.86		MK10_HUMAN (1-424): 1.16e-155: 449: 84.04
+	Hs
		547743 ATF2_HUMAN (47-331): 1.64e-38: 144: 17.33		MK09_HUMAN (1-424): 2.83e-163: 467: 100.00
+	Hs
		568073 JUND_HUMAN (5-331): 5.93e-47: 163: 45.86		MK08_HUMAN (1-424): 1.17e-153: 443: 80.80
+	Hs
		547757 ATF2_HUMAN (47-331): 1.64e-38: 144: 17.33		MK10_HUMAN (1-424): 1.16e-155: 449: 84.04
+	Hs
		547742 ATF2_HUMAN (47-331): 1.64e-38: 144: 17.33		MK08_HUMAN (1-424): 1.17e-153: 443: 80.80
+	Hs
		173828 ATF2_HUMAN (47-331): 1.64e-38: 144: 17.33		MK13_HUMAN (10-365): 2.72e-135: 394: 46.93
+	Hs
		547805 ATF2_HUMAN (47-331): 1.64e-38: 144: 17.33		MK11_HUMAN (8-363): 3.93e-133: 388: 47.08
+	Hs
		401473 JUN_HUMAN (1-331): 8.11e-87: 266: 100.00		MK01_HUMAN (15-364): 1.35e-82: 259: 40.50
+	Hs
		568066 JUND_HUMAN (5-331): 5.93e-47: 163: 45.86		MK01_HUMAN (15-364): 1.35e-82: 259: 40.50
+	Hs
		547713 ATF2_HUMAN (47-331): 1.64e-38: 144: 17.33		MK01_HUMAN (15-364): 1.35e-82: 259: 40.50