HitPredict

Interactor 1: JUN (P05412)
Transcription factor Jun (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (Transcription factor AP-1 subunit Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39)
Gene: JUN

Interactor 2: SMAD2 (Q15796)
Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2)
Gene: SMAD2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	0.60	0.660

The method score is based on:

Property	Details
Experiments	11371641, 20195357, 25609649
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation, display technology
Interaction Type	physical association, direct interaction, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific GO:0003700 - DNA-binding transcription factor activity and 11 others more... GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005667 - transcription regulator complex GO:0007179 - transforming growth factor beta receptor signaling pathway GO:0031625 - ubiquitin protein ligase binding GO:0045892 - negative regulation of DNA-templated transcription GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0060395 - SMAD protein signal transduction GO:0061629 - RNA polymerase II-specific DNA-binding transcription factor binding GO:0070412 - R-SMAD binding
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1	331
Hs

1	467

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024