HitPredict

Interactor 1: JUN (P05412)
Transcription factor Jun (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (Transcription factor AP-1 subunit Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39)
Gene: JUN

Interactor 2: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

Property	Details
Experiments	16901904, 19806201, 19818398
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0044389 - ubiquitin-like protein ligase binding
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 331 Hs			1 903
+	Mm
		404153 JUN_MOUSE (1-331): 5.76e-86: 263: 94.61		ITCH_MOUSE (1-903): 0: 885: 91.16
+	Hs
		566783 JUNB_HUMAN (1-331): 3.94e-63: 205: 43.89		ITCH_HUMAN (1-903): 0: 926: 100.00
+	Mm
		450553 JUNB_MOUSE (1-331): 1.47e-72: 229: 44.26		ITCH_MOUSE (1-903): 0: 885: 91.16
+	Hs
		401608 JUN_HUMAN (1-331): 8.11e-87: 266: 100.00		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		566791 JUNB_HUMAN (1-331): 3.94e-63: 205: 43.89		SMUF1_HUMAN (1-535): 1.85e-47: 183: 14.71
+	Mm
		808353 NF2L2_MOUSE (10-314): 8.57e-29: 118: 15.48		NEDD4_MOUSE (13-426): 2.27e-52: 199: 18.38