HitPredict

Interactor 1: LA (P05455)
Lupus La protein (La autoantigen) (La ribonucleoprotein) (Sjoegren syndrome type B antigen) (SS-B)
Gene: SSB

Interactor 2: SRSF6 (Q13247)
Serine/arginine-rich splicing factor 6 (Pre-mRNA-splicing factor SRP55) (Splicing factor, arginine/serine-rich 6)
Gene: SRSF6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	35271311, 33961781, 34349018
Identification Methods	affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	La~RRM_1, RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 408 Hs			1 344
+	Hs
		403210 LA_HUMAN (1-408): 4.97e-104: 315: 100.00		SRSF5_HUMAN (2-180): 3.02e-46: 160: 64.25
+	Hs
		403212 LA_HUMAN (1-408): 4.97e-104: 315: 100.00		PABP4_HUMAN (101-191): 1.26e-12: 70.7: 21.88
+	Mm
		857324 TIA1_MOUSE (106-327): 7.74e-43: 156: 14.16		Q542V3_MOUSE (1-343): 1.15e-52: 182: 51.93
+	Mm
		857340 TIA1_MOUSE (106-327): 7.74e-43: 156: 14.16		SRSF1_MOUSE (3-188): 3.02e-54: 180: 36.65
+	Mm
		985651 LARP7_MOUSE (10-177): 9.84e-39: 148: 31.18		SRSF1_MOUSE (3-188): 3.02e-54: 180: 36.65
+	Hs
		992797 LARP7_HUMAN (7-177): 1.36e-38: 148: 29.48		SRSF1_HUMAN (3-188): 3.02e-54: 180: 36.65
+	Hs
		474020 PAB4L_HUMAN (69-333): 1.17e-44: 160: 15.30		SRSF6_HUMAN (1-323): 3.2e-43: 154: 100.00
+	Hs
		993731 LARP7_HUMAN (7-177): 1.36e-38: 148: 29.48		SRSF4_HUMAN (1-323): 1.85e-45: 163: 63.47
+	Hs
		1028680 LARP7_HUMAN (7-177): 1.36e-38: 148: 29.48		SRSF5_HUMAN (2-180): 3.02e-46: 160: 64.25
+	At
		285478 LRP6B_ARATH (12-258): 6.05e-55: 191: 19.48		PABP8_ARATH (3-191): 6.85e-27: 113: 16.42
+	Hs
		1028941 LARP7_HUMAN (7-177): 1.36e-38: 148: 29.48		SRSF6_HUMAN (1-323): 3.2e-43: 154: 100.00
+	At
		285476 LRP6B_ARATH (12-258): 6.05e-55: 191: 19.48		PABP2_ARATH (109-194): 1.77e-11: 67.2: 24.18
+	Hs
		474021 PAB4L_HUMAN (69-333): 1.17e-44: 160: 15.30		PABP4_HUMAN (101-191): 1.26e-12: 70.7: 21.88
+	Zm
		8143 A0A1D6ELH4_MAIZE (32-322): 1.15e-44: 165: 13.81		A0A1D6ELH4_MAIZE (108-194): 1.39e-09: 61.5: 25.00
+	Mm
		665745 TIA1_MOUSE (106-327): 7.74e-43: 156: 14.16		PABP1_MOUSE (101-191): 1.39e-11: 67.6: 19.79
+	At
		790116 LRP6C_ARATH (11-202): 1.42e-42: 156: 20.59		PABP2_ARATH (109-194): 1.77e-11: 67.2: 24.18
+	Hs
		1031352 LARP7_HUMAN (7-177): 1.36e-38: 148: 29.48		PABP4_HUMAN (101-191): 1.26e-12: 70.7: 21.88
+	Hs
		474017 PAB4L_HUMAN (69-333): 1.17e-44: 160: 15.30		SRSF3_HUMAN (3-78): 2.4e-09: 57.4: 46.84
+	Hs
		516541 LARP7_HUMAN (7-177): 1.36e-38: 148: 29.48		PABP1_HUMAN (101-191): 1.28e-11: 67.6: 19.79
+	Hs
		951983 LARP7_HUMAN (7-177): 1.36e-38: 148: 29.48		SRSF3_HUMAN (3-78): 2.4e-09: 57.4: 46.84