HitPredict

Interactor 1: LA (P05455)
Lupus La protein (La autoantigen) (La ribonucleoprotein) (Sjoegren syndrome type B antigen) (SS-B)
Gene: SSB

Interactor 2: LARP7 (Q4G0J3)
La-related protein 7 (La ribonucleoprotein domain family member 7) (hLARP7) (P-TEFb-interaction protein for 7SK stability) (PIP7S)
Gene: LARP7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.847

Property	Details
Experiments	26725010, 29845934, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	La~RRM_1, RRM_1~RRM_1, RRM_3~RRM_3
Common GO terms	GO:0003723 - RNA binding GO:0003729 - mRNA binding GO:0005634 - nucleus GO:0005829 - cytosol GO:1990904 - ribonucleoprotein complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 408 Hs			1 582
+	Hs
		403212 LA_HUMAN (1-408): 4.97e-104: 315: 100.00		PABP4_HUMAN (1-208): 8.15e-41: 158: 11.98
+	At
		285476 LRP6B_ARATH (12-258): 6.05e-55: 191: 19.48		PABP2_ARATH (25-486): 1.23e-63: 222: 11.70
+	Hs
		403258 LA_HUMAN (1-408): 4.97e-104: 315: 100.00		LARP1_HUMAN (29-114): 6.35e-13: 73.8: 40.23
+	Hs
		403236 LA_HUMAN (1-408): 4.97e-104: 315: 100.00		ELAV1_HUMAN (92-211): 7.72e-13: 71.9: 22.50
+	At
		790116 LRP6C_ARATH (11-202): 1.42e-42: 156: 20.59		PABP2_ARATH (25-486): 1.23e-63: 222: 11.70
+	Hs
		474021 PAB4L_HUMAN (69-333): 1.17e-44: 160: 15.30		PABP4_HUMAN (1-208): 8.15e-41: 158: 11.98
+	Mm
		665745 TIA1_MOUSE (106-327): 7.74e-43: 156: 14.16		PABP1_MOUSE (1-405): 3.35e-40: 156: 10.05
+	Hs
		1116542 LARP7_HUMAN (7-177): 1.36e-38: 148: 29.48		PABP3_HUMAN (1-333): 6.27e-42: 162: 10.11
+	Hs
		1031352 LARP7_HUMAN (7-177): 1.36e-38: 148: 29.48		PABP4_HUMAN (1-208): 8.15e-41: 158: 11.98
+	Hs
		474033 PAB4L_HUMAN (69-333): 1.17e-44: 160: 15.30		LAR4B_HUMAN (2-216): 8.48e-36: 145: 17.02
+	Hs
		516541 LARP7_HUMAN (7-177): 1.36e-38: 148: 29.48		PABP1_HUMAN (1-405): 1.94e-40: 157: 10.29
+	Hs
		1116530 LARP7_HUMAN (7-177): 1.36e-38: 148: 29.48		MK67I_HUMAN (93-358): 1.25e-39: 148: 19.42
+	Hs
		1116423 LARP7_HUMAN (7-177): 1.36e-38: 148: 29.48		LAR4B_HUMAN (2-216): 8.48e-36: 145: 17.02
+	Hs
		474034 PAB4L_HUMAN (69-333): 1.17e-44: 160: 15.30		PABP5_HUMAN (12-206): 7.64e-32: 128: 14.15
+	At
		285478 LRP6B_ARATH (12-258): 6.05e-55: 191: 19.48		PABP8_ARATH (2-127): 5.76e-15: 80: 11.91
+	Zm
		8143 A0A1D6ELH4_MAIZE (32-322): 1.15e-44: 165: 13.81		A0A1D6ELH4_MAIZE (2-130): 7.34e-12: 70.3: 10.69
+	Mm
		857310 TIA1_MOUSE (106-327): 7.74e-43: 156: 14.16		ELAV1_MOUSE (92-211): 6.43e-13: 71.9: 22.50
+	Hs
		1116331 LARP7_HUMAN (7-177): 1.36e-38: 148: 29.48		LARP1_HUMAN (29-114): 6.35e-13: 73.8: 40.23
+	Hs
		1077384 LARP7_HUMAN (7-177): 1.36e-38: 148: 29.48		ELAV1_HUMAN (92-211): 7.72e-13: 71.9: 22.50
+	Hs
		1116304 LARP7_HUMAN (7-177): 1.36e-38: 148: 29.48		PAP1L_HUMAN (2-131): 1.6e-11: 69.2: 11.54