HitPredict

Interactor 1: SRC (P05480)
Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
Gene: SRC

Interactor 2: FAK1 (P34152)
Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK)
Gene: Ptk2

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.76 1.00 0.873

The method score is based on:

Property Details
Experiments 16966330, 10362356, 10931187, 18233957
Identification Methods affinity chromatography technology, coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains FERM_M~PK_Tyr_Ser-Thr, FERM_N_2~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms GO:0004713 - protein tyrosine kinase activity
GO:0004715 - non-membrane spanning protein tyrosine kinase activity
GO:0005178 - integrin binding
GO:0005524 - ATP binding
GO:0005634 - nucleus
and 13 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 535
Mm

1 1052
+ Gg
+ Mm
+ Rn
+ Hs
+ Mm
+ Mm
+ Hs
+ Hs
+ Hs
+ Mm
+ Rn
+ Hs
+ Hs
+ Hs
+ Mm
+ Gg
+ Hs
+ Rn
+ Hs
+ Hs

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Last updated: 15 Jul 2024