HitPredict

Interactor 1: SRC (P05480)
Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
Gene: SRC

Interactor 2: SHC3 (Q61120)
SHC-transforming protein 3 (Neuronal Shc) (N-Shc) (SHC-transforming protein C) (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3)
Gene: SHC3

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	15716419
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SH3_1
Common GO terms	GO:0005886 - plasma membrane GO:0007611 - learning or memory GO:0035556 - intracellular signal transduction
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 535 Mm			1 474
+	Mm
		403451 SRC_MOUSE (1-535): 0: 653: 100.00		SHC2_MOUSE (9-474): 1.91e-123: 373: 53.90
+	Mm
		403430 SRC_MOUSE (1-535): 0: 653: 100.00		SHC1_MOUSE (9-473): 4.83e-118: 359: 54.22
+	Hs
		522805 SRC_HUMAN (1-535): 0: 645: 98.69		SHC1_HUMAN (9-473): 2.91e-117: 357: 54.78
+	Mm
		403429 SRC_MOUSE (1-535): 0: 653: 100.00		DAB1_MOUSE (3-374): 5.4e-45: 167: 16.19
+	Hs
		523000 SRC_HUMAN (1-535): 0: 645: 98.69		SHB_HUMAN (234-470): 8.33e-48: 173: 20.41
+	Mm
		403406 SRC_MOUSE (1-535): 0: 653: 100.00		SRC_MOUSE (240-465): 7.99e-44: 163: 18.15
+	Hs
		454794 SRC_HUMAN (1-535): 0: 645: 98.69		FGR_HUMAN (232-465): 1.03e-44: 165: 19.59
+	Gg
		337663 SRC_CHICK (1-535): 0: 645: 93.83		SRC_CHICK (240-465): 4.89e-43: 161: 17.48
+	Hs
		442772 SRC_HUMAN (1-535): 0: 645: 98.69		HCK_HUMAN (240-474): 4.59e-43: 161: 17.06
+	Hs
		522734 SRC_HUMAN (1-535): 0: 645: 98.69		SRC_HUMAN (240-465): 4.71e-43: 161: 18.07
+	Rn
		1376717 SRC_RAT (1-535): 0: 646: 99.44		SRC_RAT (240-465): 3.5e-42: 159: 18.07
+	Hs
		411969 SRC_HUMAN (1-535): 0: 645: 98.69		FYN_HUMAN (232-472): 1.09e-41: 157: 17.38
+	Hs
		433231 SRC_HUMAN (1-535): 0: 645: 98.69		YES_HUMAN (227-465): 1.18e-41: 157: 18.40
+	Hs
		433222 YES_HUMAN (1-535): 0: 609: 73.85		FGR_HUMAN (232-465): 1.03e-44: 165: 19.59
+	Hs
		411946 YES_HUMAN (1-535): 0: 609: 73.85		FYN_HUMAN (232-472): 1.09e-41: 157: 17.38
+	Hs
		433215 YES_HUMAN (1-535): 0: 609: 73.85		YES_HUMAN (227-465): 1.18e-41: 157: 18.40
+	Hs
		522796 SRC_HUMAN (1-535): 0: 645: 98.69		P85A_HUMAN (374-472): 7.55e-18: 88.3: 33.01
+	Hs
		523089 SRC_HUMAN (1-535): 0: 645: 98.69		P55G_HUMAN (359-472): 4.93e-18: 88.3: 32.20
+	Hs
		129185 SRC_HUMAN (1-535): 0: 645: 98.69		P85B_HUMAN (310-471): 1.08e-17: 87.9: 17.47