HitPredict

Interactor 1: SRC (P05480)
Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
Gene: SRC

Interactor 2: SHIP1 (Q9ES52)
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145) (Phosphatidylinositol-4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship)
Gene: Inpp5d

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	16601135
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0005884 - actin filament GO:0005886 - plasma membrane GO:0035556 - intracellular signal transduction GO:0043065 - positive regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 535 Mm			1 1191
+	Hs
		433436 YES_HUMAN (1-535): 0: 609: 73.85		SHIP1_HUMAN (4-1187): 0: 868: 87.21
+	Mm
		337638 ABL1_MOUSE (50-535): 9.8e-172: 516: 40.16		SHIP1_MOUSE (1-1191): 0: 930: 100.00
+	Hs
		442867 HCK_HUMAN (1-530): 0: 566: 55.66		SHIP1_HUMAN (4-1187): 0: 868: 87.21
+	Hs
		433931 LYN_HUMAN (1-530): 0: 534: 52.92		SHIP1_HUMAN (4-1187): 0: 868: 87.21
+	Hs
		176351 LYN_HUMAN (1-530): 0: 534: 52.92		SHIP2_HUMAN (4-1109): 0: 676: 39.83
+	Hs
		69199 A9UF07_HUMAN (42-535): 1.93e-166: 517: 40.32		SHIP2_HUMAN (4-1109): 0: 676: 39.83
+	Hs
		176332 ABL1_HUMAN (50-535): 1.03e-171: 516: 40.16		SHIP2_HUMAN (4-1109): 0: 676: 39.83
+	Hs
		522919 SRC_HUMAN (1-535): 0: 645: 98.69		OCRL_HUMAN (252-815): 1.97e-151: 479: 23.16
+	Hs
		166024 FYN_HUMAN (1-535): 0: 595: 68.70		SYNJ2_HUMAN (275-1189): 8.74e-162: 522: 18.03
+	Hs
		433324 YES_HUMAN (1-535): 0: 609: 73.85		OCRL_HUMAN (252-815): 1.97e-151: 479: 23.16
+	Hs
		412137 FYN_HUMAN (1-535): 0: 595: 68.70		OCRL_HUMAN (252-815): 1.97e-151: 479: 23.16
+	Hs
		166023 ABL1_HUMAN (50-535): 1.03e-171: 516: 40.16		SYNJ2_HUMAN (275-1189): 8.74e-162: 522: 18.03
+	Hs
		411678 LCK_HUMAN (27-533): 0: 559: 54.01		OCRL_HUMAN (252-815): 1.97e-151: 479: 23.16
+	Hs
		243126 SRC_HUMAN (1-535): 0: 645: 98.69		SH21A_HUMAN (10-104): 2.15e-20: 90.1: 44.21
+	Hs
		155829 SRC_HUMAN (1-535): 0: 645: 98.69		SH21B_HUMAN (8-104): 3.51e-20: 89.7: 44.33
+	Mm
		292397 FYN_MOUSE (1-535): 0: 594: 68.52		SH21A_MOUSE (10-104): 1.81e-21: 93.2: 46.32
+	Hs
		243121 FYN_HUMAN (1-535): 0: 595: 68.70		SH21A_HUMAN (10-104): 2.15e-20: 90.1: 44.21
+	Hs
		243120 LCK_HUMAN (27-533): 0: 559: 54.01		SH21A_HUMAN (10-104): 2.15e-20: 90.1: 44.21
+	Hs
		203198 LCK_HUMAN (27-533): 0: 559: 54.01		SYNJ1_HUMAN (960-1191): 1.57e-11: 71.2: 13.62
+	Hs
		243122 LYN_HUMAN (1-530): 0: 534: 52.92		SH21A_HUMAN (10-104): 2.15e-20: 90.1: 44.21