HitPredict

Interactor 1: KIT (P05532)
Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)
Gene: KIT

Interactor 2: GRB2 (Q60631)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	1.00	0.743

Property	Details
Experiments	10679268, 10022833
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005886 - plasma membrane GO:0005911 - cell-cell junction GO:0030036 - actin cytoskeleton organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 979 Mm			1 217
+	Hs
		499253 KIT_HUMAN (1-978): 0: 795: 79.55		GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54
+	Hs
		411567 KIT_HUMAN (1-978): 0: 795: 79.55		LCK_HUMAN (3-202): 7.66e-38: 138: 28.91
+	Mm
		403536 KIT_MOUSE (1-979): 0: 823: 96.85		VAV_MOUSE (3-60): 1.12e-15: 76.9: 43.10
+	Hs
		499266 KIT_HUMAN (1-978): 0: 795: 79.55		PTK6_HUMAN (4-141): 7.14e-23: 97.1: 38.93
+	Hs
		499225 KIT_HUMAN (1-978): 0: 795: 79.55		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		337322 KIT_HUMAN (1-978): 0: 795: 79.55		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		499244 KIT_HUMAN (1-978): 0: 795: 79.55		ABL2_HUMAN (4-139): 9.7e-22: 94.7: 34.04
+	Mm
		292679 KIT_MOUSE (1-979): 0: 823: 96.85		GRAP2_MOUSE (3-55): 1.77e-10: 61.1: 37.74
+	Hs
		411962 KIT_HUMAN (1-978): 0: 795: 79.55		FYN_HUMAN (161-215): 4.88e-13: 69.2: 31.58
+	Hs
		499291 KIT_HUMAN (1-978): 0: 795: 79.55		VAV3_HUMAN (3-57): 6.2e-13: 69: 38.18
+	Hs
		499264 KIT_HUMAN (1-978): 0: 795: 79.55		GRAP_HUMAN (3-57): 2.36e-13: 68: 36.36
+	Hs
		433226 KIT_HUMAN (1-978): 0: 795: 79.55		YES_HUMAN (75-215): 5.41e-12: 66.1: 18.37
+	Hs
		454791 KIT_HUMAN (1-978): 0: 795: 79.55		FGR_HUMAN (161-215): 5.31e-12: 66.1: 33.33
+	Hs
		442765 KIT_HUMAN (1-978): 0: 795: 79.55		HCK_HUMAN (116-215): 1.24e-11: 64.9: 19.61
+	Hs
		275165 KIT_HUMAN (1-978): 0: 795: 79.55		GRAP2_HUMAN (3-55): 7.92e-11: 62.5: 39.62
+	Hs
		499222 KIT_HUMAN (1-978): 0: 795: 79.55		SRC_HUMAN (160-215): 1.74e-10: 61.9: 31.03
+	Hs
		433539 KIT_HUMAN (1-978): 0: 795: 79.55		LYN_HUMAN (136-215): 4.12e-10: 60.7: 24.39
+	Mm
		452181 CSF1R_MOUSE (34-935): 0: 649: 37.84		FYN_MOUSE (161-215): 4.88e-13: 69.2: 31.58
+	Mm
		403408 CSF1R_MOUSE (34-935): 0: 649: 37.84		SRC_MOUSE (80-215): 1.5e-10: 61.9: 17.24
+	Mm
		292680 CSF1R_MOUSE (34-935): 0: 649: 37.84		GRAP2_MOUSE (3-55): 1.77e-10: 61.1: 37.74