HitPredict

Interactor 1: KIT (P05532)
Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)
Gene: KIT

Interactor 2: GRB10 (Q60760)
Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Maternally expressed gene 1 protein)
Gene: GRB10

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.42	0.80	0.584

Property	Details
Experiments	11809791
Identification Methods	two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	BPS~PK_Tyr_Ser-Thr, PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 979 Mm			1 621
+	Hs
		499267 KIT_HUMAN (1-978): 0: 795: 79.55		GRB7_HUMAN (149-621): 2.61e-175: 510: 51.98
+	Mm
		403536 KIT_MOUSE (1-979): 0: 823: 96.85		VAV_MOUSE (201-615): 7.39e-83: 279: 15.26
+	Hs
		499291 KIT_HUMAN (1-978): 0: 795: 79.55		VAV3_HUMAN (201-615): 6.78e-62: 222: 11.67
+	Hs
		499242 KIT_HUMAN (1-978): 0: 795: 79.55		TEC_HUMAN (321-617): 2.91e-59: 211: 13.17
+	Hs
		499263 KIT_HUMAN (1-978): 0: 795: 79.55		GRB10_HUMAN (3-116): 2.24e-55: 199: 66.95
+	Mm
		403538 KIT_MOUSE (1-979): 0: 823: 96.85		MATK_MOUSE (435-615): 5.63e-45: 169: 22.16
+	Hs
		433226 KIT_HUMAN (1-978): 0: 795: 79.55		YES_HUMAN (471-619): 7.84e-48: 177: 21.43
+	Hs
		442765 KIT_HUMAN (1-978): 0: 795: 79.55		HCK_HUMAN (455-616): 6.74e-48: 177: 21.77
+	Hs
		411962 KIT_HUMAN (1-978): 0: 795: 79.55		FYN_HUMAN (458-618): 3.63e-47: 175: 19.64
+	Hs
		433539 KIT_HUMAN (1-978): 0: 795: 79.55		LYN_HUMAN (433-617): 2.53e-47: 175: 20.21
+	Hs
		411567 KIT_HUMAN (1-978): 0: 795: 79.55		LCK_HUMAN (447-616): 1.25e-46: 173: 19.66
+	Hs
		454791 KIT_HUMAN (1-978): 0: 795: 79.55		FGR_HUMAN (467-617): 2.38e-46: 173: 18.59
+	Hs
		499222 KIT_HUMAN (1-978): 0: 795: 79.55		SRC_HUMAN (445-617): 1.84e-44: 168: 19.44
+	Hs
		499249 KIT_HUMAN (1-978): 0: 795: 79.55		BLK_HUMAN (444-620): 1.43e-43: 165: 20.88
+	Hs
		499287 KIT_HUMAN (1-978): 0: 795: 79.55		SLAP2_HUMAN (444-617): 3.51e-43: 157: 20.67
+	Hs
		499241 KIT_HUMAN (1-978): 0: 795: 79.55		MATK_HUMAN (482-614): 1.18e-39: 154: 27.74
+	Hs
		499230 KIT_HUMAN (1-978): 0: 795: 79.55		PLCG1_HUMAN (401-618): 1.07e-27: 121: 17.19
+	Mm
		403541 KIT_MOUSE (1-979): 0: 823: 96.85		GRB2_MOUSE (519-602): 5.63e-14: 73.2: 32.14
+	Hs
		499246 KIT_HUMAN (1-978): 0: 795: 79.55		KSYK_HUMAN (508-614): 6.77e-13: 73.6: 28.97
+	Hs
		499253 KIT_HUMAN (1-978): 0: 795: 79.55		GRB2_HUMAN (519-602): 5.63e-14: 73.2: 32.14