HitPredict

Interactor 1: ITB1 (P05556)
Integrin beta-1 (Fibronectin receptor subunit beta) (Glycoprotein IIa) (GPIIA) (VLA-4 subunit beta) (CD antigen CD29)
Gene: ITGB1

Interactor 2: ITA3 (P26006)
Integrin alpha-3 (CD49 antigen-like family member C) (FRP-2) (Galactoprotein B3) (GAPB3) (VLA-3 subunit alpha) (CD antigen CD49c) [Cleaved into: Integrin alpha-3 heavy chain; Integrin alpha-3 light chain]
Gene: ITGA3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.78 1.00 0.886

The method score is based on:

Property Details
Experiments 15254262, 30021884, 16878156, 15181153
Identification Methods pull down, proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation, cross-linking study
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains EGF_2~Integrin_alpha2, I-EGF_1~Integrin_alpha2, Integrin_B_tail~Integrin_alpha2, FG-GAP~Integrin_beta, Integrin_alpha2~Integrin_beta, Integrin_alpha2~PSI_integrin
Common GO terms GO:0001968 - fibronectin binding
GO:0002020 - protease binding
GO:0005178 - integrin binding
GO:0005886 - plasma membrane
GO:0005925 - focal adhesion
and 18 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024