HitPredict

Interactor 1: KPCB (P05771)
Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13)
Gene: PRKCB

Interactor 2: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 671 Hs			1 685
+	Hs
		475314 KPCA_HUMAN (1-668): 0: 742: 78.89		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		475390 AKT1_HUMAN (239-665): 2.36e-159: 469: 37.33		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		475345 KS6B1_HUMAN (291-671): 1.04e-153: 456: 36.83		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		475450 KPCI_HUMAN (10-86): 4.39e-13: 74.3: 40.26		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		475653 KPCZ_HUMAN (10-86): 4.47e-12: 71.2: 36.36		UBC_HUMAN (1-685): 0: 846: 100.00
+	Rn
		934619 KPCB_RAT (1-671): 0: 772: 98.81		UBC_RAT (1-108): 1.27e-29: 127: 90.74
+	Hs
		408534 KPCB_HUMAN (1-671): 0: 774: 100.00		UBB_HUMAN (1-77): 7.83e-26: 108: 98.70
+	Rn
		930581 KPCG_RAT (17-668): 0: 673: 67.96		UBC_RAT (1-108): 1.27e-29: 127: 90.74
+	Hs
		923962 KPCE_HUMAN (5-662): 0: 624: 44.73		RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00
+	Rn
		448416 KPCE_RAT (5-662): 0: 619: 44.73		UBC_RAT (1-108): 1.27e-29: 127: 90.74
+	Hs
		681773 AKT1_HUMAN (239-665): 2.36e-159: 469: 37.33		RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00
+	Hs
		474935 AKT1_HUMAN (239-665): 2.36e-159: 469: 37.33		UBB_HUMAN (1-77): 7.83e-26: 108: 98.70
+	Hs
		474936 AKT2_HUMAN (237-665): 2.34e-159: 469: 37.87		UBB_HUMAN (1-77): 7.83e-26: 108: 98.70
+	Rn
		448410 KPCD_RAT (6-176): 8.35e-54: 197: 37.08		UBC_RAT (1-108): 1.27e-29: 127: 90.74
+	Mm
		476830 KPCI_MOUSE (10-86): 5.08e-13: 74.3: 40.26		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74