HitPredict

Interactor 1: KPCB (P05771)
Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13)
Gene: PRKCB

Interactor 2: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.60	0.619

Property	Details
Experiments	11104762, 35063084
Identification Methods	enzymatic study, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 671 Hs			1 758
+	Hs
		496245 KPCA_HUMAN (1-668): 0: 742: 78.89		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Rn
		581978 KPCB_RAT (1-671): 0: 772: 98.81		TAU_RAT (1-758): 4.86e-75: 260: 71.47
+	Rn
		94201 KPCB_RAT (1-671): 0: 772: 98.81		F1LST4_RAT (1-757): 8.59e-75: 260: 71.56
+	Hs
		397126 KPCG_HUMAN (1-668): 0: 678: 66.96		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		496879 KPCE_HUMAN (5-662): 0: 624: 44.73		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Mm
		497997 KPCG_MOUSE (17-668): 0: 673: 67.96		TAU_MOUSE (1-758): 1.4e-69: 244: 70.17
+	Hs
		496407 AKT1_HUMAN (239-665): 2.36e-159: 469: 37.33		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		496408 AKT2_HUMAN (237-665): 2.34e-159: 469: 37.87		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		496317 KS6B1_HUMAN (291-671): 1.04e-153: 456: 36.83		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		152597 AKT1_HUMAN (239-665): 2.36e-159: 469: 37.33		KMT2D_HUMAN (226-636): 8.62e-26: 116: 19.55
+	Hs
		496492 KPCI_HUMAN (10-86): 4.39e-13: 74.3: 40.26		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		496900 KPCZ_HUMAN (10-86): 4.47e-12: 71.2: 36.36		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		554297 KPCD_HUMAN (6-167): 1.49e-54: 199: 40.83		MUC1_HUMAN (242-751): 2.66e-25: 114: 10.84