HitPredict

Interactor 1: KPCB (P05771)
Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13)
Gene: PRKCB

Interactor 2: HMGB2 (P26583)
High mobility group protein B2 (High mobility group protein 2) (HMG-2)
Gene: HMGB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 671 Hs			1 209
+	Rn
		927937 KPCB_RAT (1-671): 0: 772: 98.81		HMGB1_RAT (1-174): 3.53e-42: 143: 86.21
+	Hs
		566339 KPCA_HUMAN (1-668): 0: 742: 78.89		SOX10_HUMAN (2-98): 5.81e-22: 94.4: 16.50
+	Rn
		927936 KPCG_RAT (17-668): 0: 673: 67.96		HMGB1_RAT (1-174): 3.53e-42: 143: 86.21
+	Dm
		1213418 AKT1_DROME (148-662): 2.28e-153: 458: 34.74		Q9VUD3_DROME (2-95): 1.18e-27: 110: 20.21
+	Hs
		681734 AKT1_HUMAN (239-665): 2.36e-159: 469: 37.33		SOX2_HUMAN (3-94): 2.29e-23: 96.7: 22.83
+	Hs
		681805 AKT1_HUMAN (239-665): 2.36e-159: 469: 37.33		SOX4_HUMAN (3-89): 1.9e-19: 87.4: 20.69
+	Hs
		1298808 AKT3_HUMAN (284-665): 4.8e-158: 465: 41.48		TOX2_HUMAN (91-142): 1.64e-18: 84.8: 36.54
+	Rn
		448408 KPCD_RAT (6-176): 8.35e-54: 197: 37.08		HMGB1_RAT (1-174): 3.53e-42: 143: 86.21
+	Hs
		817958 KPCD_HUMAN (6-167): 1.49e-54: 199: 40.83		SOX2_HUMAN (3-94): 2.29e-23: 96.7: 22.83
+	Hs
		449691 KPCZ_HUMAN (10-86): 4.47e-12: 71.2: 36.36		HMGB1_HUMAN (1-174): 3.53e-42: 143: 86.21
+	Hs
		643334 KPCZ_HUMAN (10-86): 4.47e-12: 71.2: 36.36		HMGB2_HUMAN (1-187): 3.05e-41: 140: 100.00
+	Hs
		783949 KPCI_HUMAN (10-86): 4.39e-13: 74.3: 40.26		SOX2_HUMAN (3-94): 2.29e-23: 96.7: 22.83