HitPredict

Interactor 1: KPCB (P05771)
Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13)
Gene: PRKCB

Interactor 2: RACK1 (P63244)
Small ribosomal subunit protein RACK1 (Cell proliferation-inducing gene 21 protein) (Guanine nucleotide-binding protein subunit beta-2-like 1) (Guanine nucleotide-binding protein subunit beta-like protein 12.3) (Human lung cancer oncogene 7 protein) (HLC-7) (Receptor for activated C kinase) (Receptor of activated protein C kinase 1) [Cleaved into: Small ribosomal subunit protein RACK1, N-terminally processed (Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed) (Receptor of activated protein C kinase 1, N-terminally processed)]
Gene: RACK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.702

Property	Details
Experiments	10480917, 18596232, 24681954, 23866081
Identification Methods	pull down, affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005080 - protein kinase C binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 671 Hs			1 317
+	Mm
		932614 KPCB_MOUSE (1-671): 0: 772: 98.81		RACK1_MOUSE (1-317): 2.18e-109: 322: 100.00
+	Hs
		566350 KPCA_HUMAN (1-668): 0: 742: 78.89		RACK1_HUMAN (1-317): 2.18e-109: 322: 100.00
+	Mm
		934635 KPCB_MOUSE (1-671): 0: 772: 98.81		FBXW7_MOUSE (3-255): 1.29e-66: 222: 23.19
+	Mm
		593490 KPCA_MOUSE (1-668): 0: 735: 78.14		FBXW7_MOUSE (3-255): 1.29e-66: 222: 23.19
+	Hs
		929405 KPCE_HUMAN (5-662): 0: 624: 44.73		RACK1_HUMAN (1-317): 2.18e-109: 322: 100.00
+	Mm
		554925 KPCE_MOUSE (5-662): 0: 624: 45.02		FBXW7_MOUSE (3-255): 1.29e-66: 222: 23.19
+	Sp
		736861 PCK2_SCHPO (18-670): 0: 570: 35.44		GBLP_SCHPO (100-316): 8.23e-54: 180: 26.75
+	Dm
		186204 AKT1_DROME (148-662): 2.28e-153: 458: 34.74		GBLP_DROME (93-316): 4.19e-49: 167: 22.88
+	Hs
		681967 AKT1_HUMAN (239-665): 2.36e-159: 469: 37.33		FBXW7_HUMAN (3-128): 4.32e-21: 95.4: 24.63
+	Mm
		661011 KPCD_MOUSE (6-194): 5.27e-54: 198: 35.20		FBXW7_MOUSE (3-255): 1.29e-66: 222: 23.19
+	Hs
		929411 KPCZ_HUMAN (10-86): 4.47e-12: 71.2: 36.36		RACK1_HUMAN (1-317): 2.18e-109: 322: 100.00
+	Mm
		973813 KPCZ_MOUSE (10-86): 5.5e-12: 70.9: 36.36		FBXW7_MOUSE (3-255): 1.29e-66: 222: 23.19
+	Sc
		623462 KPC1_YEAST (12-344): 5.78e-45: 175: 17.49		GBLP_YEAST (5-138): 5.08e-18: 84.6: 19.68