HitPredict

Interactor 1: KPCB (P05771)
Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13)
Gene: PRKCB

Interactor 2: PHLP2 (Q6ZVD8)
PH domain leucine-rich repeat-containing protein phosphatase 2 (EC 3.1.3.16) (PH domain leucine-rich repeat-containing protein phosphatase-like) (PHLPP-like)
Gene: PHLPP2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	18162466
Identification Methods	anti tag coimmunoprecipitation, cosedimentation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	LRR_6~Pkinase, PP2C~Pkinase
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 671 Hs			1 1323
+	Hs
		232762 KPCB_HUMAN (1-671): 0: 774: 100.00		PHLP1_HUMAN (36-1300): 0: 845: 53.04
+	Hs
		681911 AKT1_HUMAN (239-665): 2.36e-159: 469: 37.33		PHLP2_HUMAN (1-1323): 0: 993: 100.00
+	Hs
		682190 AKT2_HUMAN (237-665): 2.34e-159: 469: 37.87		PHLP2_HUMAN (1-1323): 0: 993: 100.00
+	Hs
		1172970 AKT3_HUMAN (284-665): 4.8e-158: 465: 41.48		PHLP2_HUMAN (1-1323): 0: 993: 100.00
+	Hs
		616717 KS6B1_HUMAN (291-671): 1.04e-153: 456: 36.83		PHLP2_HUMAN (1-1323): 0: 993: 100.00
+	Rn
		88885 AKT1_RAT (239-665): 9.61e-160: 470: 37.10		D4A254_RAT (1-1323): 0: 977: 92.60
+	Hs
		232791 AKT1_HUMAN (239-665): 2.36e-159: 469: 37.33		PHLP1_HUMAN (36-1300): 0: 845: 53.04
+	Hs
		232792 AKT2_HUMAN (237-665): 2.34e-159: 469: 37.87		PHLP1_HUMAN (36-1300): 0: 845: 53.04
+	Hs
		233019 AKT3_HUMAN (284-665): 4.8e-158: 465: 41.48		PHLP1_HUMAN (36-1300): 0: 845: 53.04
+	Hs
		232782 KS6B1_HUMAN (291-671): 1.04e-153: 456: 36.83		PHLP1_HUMAN (36-1300): 0: 845: 53.04
+	Hs
		566388 KPCA_HUMAN (1-668): 0: 742: 78.89		SCRIB_HUMAN (438-732): 2.62e-12: 73.9: 29.00
+	Hs
		784073 KPCI_HUMAN (10-86): 4.39e-13: 74.3: 40.26		ERBIN_HUMAN (461-746): 7.29e-10: 65.9: 24.75