HitPredict

Interactor 1: K1C18 (P05783)
Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18)
Gene: KRT18

Interactor 2: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.678

Property	Details
Experiments	26618866, 31324722, 29924966, 22038833
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 430 Hs			1 1480
+	Hs
		529780 KRT84_HUMAN (42-391): 2.06e-98: 308: 28.00		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		529119 KRT81_HUMAN (12-391): 1.24e-92: 290: 24.87		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		213928 KRT86_HUMAN (12-391): 3.53e-91: 285: 24.87		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		529151 K1H1_HUMAN (79-392): 1.28e-90: 282: 47.94		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		359298 K1C14_HUMAN (77-428): 5.85e-89: 279: 49.58		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		280490 KT33A_HUMAN (79-385): 1.91e-89: 278: 48.38		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		444303 K1C19_HUMAN (79-389): 5.66e-89: 277: 50.64		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		444998 K1C16_HUMAN (77-404): 2.34e-87: 275: 49.85		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		529118 KT33B_HUMAN (79-385): 4.54e-87: 272: 47.40		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		528449 K1C13_HUMAN (57-389): 1.38e-85: 270: 48.96		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		529011 K1C17_HUMAN (58-420): 5.11e-86: 270: 48.08		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		318772 K2C75_HUMAN (4-400): 1.01e-83: 268: 24.50		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		280518 KRT34_HUMAN (79-385): 1.5e-82: 260: 44.81		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		529194 K1C24_HUMAN (80-388): 4.27e-81: 260: 50.48		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		529130 K2C72_HUMAN (2-395): 5.65e-79: 255: 24.24		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		528450 K2C5_HUMAN (45-400): 2.97e-73: 242: 25.70		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		380440 K2C6B_HUMAN (45-406): 4.05e-73: 241: 23.90		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		528760 K2C6C_HUMAN (45-406): 3.96e-73: 241: 24.18		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		529503 KRT35_HUMAN (4-391): 7.57e-74: 240: 40.87		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		359458 K2C6A_HUMAN (45-406): 1.72e-71: 236: 23.90		CFTR_HUMAN (1-1480): 0: 1031: 100.00