HitPredict

Interactor 1: K1C18 (P05783)
Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18)
Gene: KRT18

Interactor 2: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.684

Property	Details
Experiments	9524113, 36931259, 20618440, 10954706
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 430 Hs			1 245
+	Mm
		408972 K1C18_MOUSE (12-430): 5.27e-157: 452: 85.95		1433Z_MOUSE (1-245): 3.06e-142: 399: 80.00
+	Mm
		250878 K1C17_MOUSE (26-421): 1.74e-142: 415: 44.84		1433S_MOUSE (1-232): 2e-106: 309: 72.65
+	Hs
		444319 K1C19_HUMAN (79-389): 5.66e-89: 277: 50.64		1433T_HUMAN (1-245): 9.47e-142: 398: 100.00
+	Hs
		444348 K1C19_HUMAN (79-389): 5.66e-89: 277: 50.64		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Hs
		646819 K1C17_HUMAN (58-420): 5.11e-86: 270: 48.08		1433T_HUMAN (1-245): 9.47e-142: 398: 100.00
+	Hs
		926952 K1C17_HUMAN (58-420): 5.11e-86: 270: 48.08		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Mm
		910243 K22O_MOUSE (42-400): 2.17e-73: 242: 22.59		1433E_MOUSE (2-243): 1.31e-144: 406: 63.53
+	Hs
		408772 K1C18_HUMAN (1-430): 1.32e-72: 236: 100.00		1433E_HUMAN (2-243): 1.31e-144: 406: 63.53
+	Hs
		380460 K2C6B_HUMAN (45-406): 4.05e-73: 241: 23.90		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Hs
		408744 K1C18_HUMAN (1-430): 1.32e-72: 236: 100.00		1433B_HUMAN (1-242): 5.01e-139: 391: 81.82
+	Hs
		444322 K1C19_HUMAN (79-389): 5.66e-89: 277: 50.64		1433S_HUMAN (1-236): 9.86e-108: 312: 71.85
+	Hs
		904588 K1H1_HUMAN (79-392): 1.28e-90: 282: 47.94		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33
+	Hs
		444355 K1C19_HUMAN (79-389): 5.66e-89: 277: 50.64		1433F_HUMAN (2-242): 7.16e-106: 307: 71.43
+	Hs
		444343 K1C19_HUMAN (79-389): 5.66e-89: 277: 50.64		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33
+	Hs
		904559 KT33B_HUMAN (79-385): 4.54e-87: 272: 47.40		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33
+	Hs
		905163 KRT82_HUMAN (12-391): 1.15e-84: 269: 25.98		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33
+	Hs
		280557 KRT34_HUMAN (79-385): 1.5e-82: 260: 44.81		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33
+	Hs
		408745 K1C18_HUMAN (1-430): 1.32e-72: 236: 100.00		1433S_HUMAN (1-236): 9.86e-108: 312: 71.85
+	Hs
		904944 KRT35_HUMAN (4-391): 7.57e-74: 240: 40.87		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33
+	Hs
		408770 K1C18_HUMAN (1-430): 1.32e-72: 236: 100.00		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33