HitPredict

Interactor 1: K1C18 (P05783)
Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18)
Gene: KRT18

Interactor 2: PML (P29590)
Protein PML (E3 SUMO-protein ligase PML) (EC 2.3.2.-) (Promyelocytic leukemia protein) (RING finger protein 71) (RING-type E3 SUMO transferase PML) (Tripartite motif-containing protein 19) (TRIM19)
Gene: PML

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	34795231, 36880596
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005730 - nucleolus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016363 - nuclear matrix GO:0097191 - extrinsic apoptotic signaling pathway
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 430 Hs			1 882
+	Hs
		1071441 K1H1_HUMAN (79-392): 1.28e-90: 282: 47.94		TRIM1_HUMAN (48-412): 7.57e-53: 199: 14.67
+	Hs
		584934 K1C17_HUMAN (58-420): 5.11e-86: 270: 48.08		RO52_HUMAN (44-414): 8.03e-56: 202: 13.46
+	Hs
		359339 K1C14_HUMAN (77-428): 5.85e-89: 279: 49.58		TRI26_HUMAN (45-399): 8.61e-52: 192: 12.87
+	Hs
		444359 K1C19_HUMAN (79-389): 5.66e-89: 277: 50.64		TRI26_HUMAN (45-399): 8.61e-52: 192: 12.87
+	Hs
		318903 K2C75_HUMAN (4-400): 1.01e-83: 268: 24.50		TRIM1_HUMAN (48-412): 7.57e-53: 199: 14.67
+	Hs
		445039 K1C16_HUMAN (77-404): 2.34e-87: 275: 49.85		TRI26_HUMAN (45-399): 8.61e-52: 192: 12.87
+	Hs
		380469 K2C6B_HUMAN (45-406): 4.05e-73: 241: 23.90		TRI26_HUMAN (45-399): 8.61e-52: 192: 12.87
+	Hs
		408790 K1C18_HUMAN (1-430): 1.32e-72: 236: 100.00		TRI26_HUMAN (45-399): 8.61e-52: 192: 12.87
+	Hs
		408933 K1C18_HUMAN (1-430): 1.32e-72: 236: 100.00		TRI36_HUMAN (55-384): 5.81e-17: 87.9: 18.51