HitPredict

Interactor 1: K1C18 (P05783)
Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18)
Gene: KRT18

Interactor 2: EPIPL (P58107)
Epiplakin (450 kDa epidermal antigen)
Gene: EPPK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	34079125, 35271311
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005198 - structural molecule activity GO:0005737 - cytoplasm GO:0005856 - cytoskeleton GO:0045095 - keratin filament and 1 others more... GO:0071944 - cell periphery
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 430 Hs			1 5088
+	Hs
		213934 KRT86_HUMAN (12-391): 3.53e-91: 285: 24.87		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Hs
		885269 K2C73_HUMAN (2-395): 2.54e-90: 285: 25.06		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Hs
		885254 K1H1_HUMAN (79-392): 1.28e-90: 282: 47.94		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Hs
		359323 K1C14_HUMAN (77-428): 5.85e-89: 279: 49.58		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Hs
		885247 KT33B_HUMAN (79-385): 4.54e-87: 272: 47.40		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Hs
		885321 KRT82_HUMAN (12-391): 1.15e-84: 269: 25.98		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Hs
		318791 K2C75_HUMAN (4-400): 1.01e-83: 268: 24.50		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Hs
		885251 K2C72_HUMAN (2-395): 5.65e-79: 255: 24.24		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Rn
		513772 K1C19_RAT (79-388): 1.47e-92: 286: 52.41		DMD_RAT (1908-3539): 9.79e-136: 484: 10.58
+	Mm
		513795 K1C40_MOUSE (79-385): 6.52e-82: 260: 43.51		DMD_MOUSE (1908-3539): 4.34e-135: 482: 10.64
+	Hs
		359355 K1C14_HUMAN (77-428): 5.85e-89: 279: 49.58		PLEC_HUMAN (1149-4489): 2.53e-72: 275: 17.38
+	Hs
		444372 K1C19_HUMAN (79-389): 5.66e-89: 277: 50.64		PLEC_HUMAN (1149-4489): 2.53e-72: 275: 17.38
+	Hs
		445052 K1C16_HUMAN (77-404): 2.34e-87: 275: 49.85		PLEC_HUMAN (1149-4489): 2.53e-72: 275: 17.38
+	Hs
		280584 KRT34_HUMAN (79-385): 1.5e-82: 260: 44.81		PLEC_HUMAN (1149-4489): 2.53e-72: 275: 17.38
+	Hs
		444307 K1C19_HUMAN (79-389): 5.66e-89: 277: 50.64		DESP_HUMAN (2873-5087): 3.05e-30: 135: 10.82
+	Hs
		551676 K1C17_HUMAN (58-420): 5.11e-86: 270: 48.08		DESP_HUMAN (2873-5087): 3.05e-30: 135: 10.82
+	Hs
		444425 K1C19_HUMAN (79-389): 5.66e-89: 277: 50.64		NIN_HUMAN (2307-3806): 1.16e-14: 84: 9.19
+	Hs
		1071210 K1H1_HUMAN (79-392): 1.28e-90: 282: 47.94		MYOME_HUMAN (2672-3762): 2.03e-12: 76.7: 12.20
+	Hs
		974058 K1C17_HUMAN (58-420): 5.11e-86: 270: 48.08		DYST_HUMAN (251-3746): 3.34e-15: 85.9: 10.46
+	Hs
		444301 K1C19_HUMAN (79-389): 5.66e-89: 277: 50.64		DMD_HUMAN (1909-3327): 6.13e-09: 65.1: 11.08