HitPredict

Interactor 1: K1C18 (P05783)
Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18)
Gene: KRT18

Interactor 2: TCHP (Q9BT92)
Trichoplein keratin filament-binding protein (Protein TCHP) (Mitochondrial protein with oncostatic activity) (Mitostatin) (Tumor suppressor protein)
Gene: TCHP

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.606

Property	Details
Experiments	15731013, 34079125
Identification Methods	two hybrid, pull down, proximity labelling technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0045095 - keratin filament
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 430 Hs			1 498
+	Hs
		359403 K1C14_HUMAN (77-428): 5.85e-89: 279: 49.58		TCHP_HUMAN (1-498): 6.62e-60: 206: 100.00
+	Hs
		444469 K1C19_HUMAN (79-389): 5.66e-89: 277: 50.64		TCHP_HUMAN (1-498): 6.62e-60: 206: 100.00
+	Hs
		445110 K1C16_HUMAN (77-404): 2.34e-87: 275: 49.85		TCHP_HUMAN (1-498): 6.62e-60: 206: 100.00
+	Hs
		580090 K1C15_HUMAN (79-420): 2.92e-87: 275: 48.28		TCHP_HUMAN (1-498): 6.62e-60: 206: 100.00
+	Hs
		318873 K2C75_HUMAN (4-400): 1.01e-83: 268: 24.50		TCHP_HUMAN (1-498): 6.62e-60: 206: 100.00
+	Hs
		1101640 K1C24_HUMAN (80-388): 4.27e-81: 260: 50.48		TCHP_HUMAN (1-498): 6.62e-60: 206: 100.00
+	Hs
		280707 KRT34_HUMAN (79-385): 1.5e-82: 260: 44.81		TCHP_HUMAN (1-498): 6.62e-60: 206: 100.00
+	Hs
		531622 K2C5_HUMAN (45-400): 2.97e-73: 242: 25.70		TCHP_HUMAN (1-498): 6.62e-60: 206: 100.00
+	Hs
		1270301 KRT35_HUMAN (4-391): 7.57e-74: 240: 40.87		TCHP_HUMAN (1-498): 6.62e-60: 206: 100.00
+	Hs
		359528 K2C6A_HUMAN (45-406): 1.72e-71: 236: 23.90		TCHP_HUMAN (1-498): 6.62e-60: 206: 100.00
+	Hs
		1055193 K1H2_HUMAN (32-400): 2.55e-72: 235: 40.81		TCHP_HUMAN (1-498): 6.62e-60: 206: 100.00
+	Hs
		408831 K1C18_HUMAN (1-430): 1.32e-72: 236: 100.00		MRCKA_HUMAN (91-492): 8.02e-27: 117: 12.10
+	Hs
		1071336 K1H1_HUMAN (79-392): 1.28e-90: 282: 47.94		CFA53_HUMAN (141-495): 4.49e-11: 67: 14.37
+	Hs
		1071283 K1H1_HUMAN (79-392): 1.28e-90: 282: 47.94		GG6L2_HUMAN (16-365): 7.73e-09: 60.5: 13.39
+	Hs
		724787 K1C17_HUMAN (58-420): 5.11e-86: 270: 48.08		MYH9_HUMAN (12-482): 7.23e-12: 70.1: 12.68
+	Hs
		725143 K1C17_HUMAN (58-420): 5.11e-86: 270: 48.08		MYH10_HUMAN (13-495): 1.16e-11: 69.7: 10.77
+	Hs
		1055068 KT33B_HUMAN (79-385): 4.54e-87: 272: 47.40		GG6L2_HUMAN (16-365): 7.73e-09: 60.5: 13.39
+	Hs
		280692 KRT34_HUMAN (79-385): 1.5e-82: 260: 44.81		CFA53_HUMAN (141-495): 4.49e-11: 67: 14.37