HitPredict

Interactor 1: K1C18 (P05783)
Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18)
Gene: KRT18

Interactor 2: HDAC6 (Q9UBN7)
Histone deacetylase 6 (HD6) (EC 3.5.1.98) (Protein deacetylase HDAC6) (EC 3.5.1.-) (Tubulin-lysine deacetylase HDAC6) (EC 3.5.1.-)
Gene: HDAC6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	26643866, 35676659
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 430 Hs			1 1215
+	Hs
		359426 K1C14_HUMAN (77-428): 5.85e-89: 279: 49.58		HDAC6_HUMAN (1-1215): 0: 1435: 100.00
+	Hs
		445135 K1C16_HUMAN (77-404): 2.34e-87: 275: 49.85		HDAC6_HUMAN (1-1215): 0: 1435: 100.00
+	Hs
		980333 K1C17_HUMAN (58-420): 5.11e-86: 270: 48.08		HDAC6_HUMAN (1-1215): 0: 1435: 100.00
+	Hs
		1101648 K1C24_HUMAN (80-388): 4.27e-81: 260: 50.48		HDAC6_HUMAN (1-1215): 0: 1435: 100.00
+	Hs
		531642 K2C5_HUMAN (45-400): 2.97e-73: 242: 25.70		HDAC6_HUMAN (1-1215): 0: 1435: 100.00
+	Hs
		380527 K2C6B_HUMAN (45-406): 4.05e-73: 241: 23.90		HDAC6_HUMAN (1-1215): 0: 1435: 100.00
+	Hs
		359541 K2C6A_HUMAN (45-406): 1.72e-71: 236: 23.90		HDAC6_HUMAN (1-1215): 0: 1435: 100.00
+	Hs
		359391 K1C14_HUMAN (77-428): 5.85e-89: 279: 49.58		HDAC2_HUMAN (78-489): 1.04e-157: 481: 21.02
+	Hs
		445095 K1C16_HUMAN (77-404): 2.34e-87: 275: 49.85		HDAC2_HUMAN (78-489): 1.04e-157: 481: 21.02
+	Hs
		880733 K1H1_HUMAN (79-392): 1.28e-90: 282: 47.94		HDAC4_HUMAN (405-873): 1.97e-147: 474: 36.51
+	Hs
		980300 K1C17_HUMAN (58-420): 5.11e-86: 270: 48.08		HDAC2_HUMAN (78-489): 1.04e-157: 481: 21.02
+	Hs
		880725 KT33B_HUMAN (79-385): 4.54e-87: 272: 47.40		HDAC4_HUMAN (405-873): 1.97e-147: 474: 36.51
+	Hs
		280553 KRT34_HUMAN (79-385): 1.5e-82: 260: 44.81		HDAC4_HUMAN (405-873): 1.97e-147: 474: 36.51
+	Hs
		531612 K2C5_HUMAN (45-400): 2.97e-73: 242: 25.70		HDAC2_HUMAN (78-489): 1.04e-157: 481: 21.02
+	Hs
		380506 K2C6B_HUMAN (45-406): 4.05e-73: 241: 23.90		HDAC2_HUMAN (78-489): 1.04e-157: 481: 21.02
+	Hs
		359520 K2C6A_HUMAN (45-406): 1.72e-71: 236: 23.90		HDAC2_HUMAN (78-489): 1.04e-157: 481: 21.02
+	Hs
		880798 KRT35_HUMAN (4-391): 7.57e-74: 240: 40.87		HDAC4_HUMAN (405-873): 1.97e-147: 474: 36.51