HitPredict

Interactor 1: K2C8 (P05787)
Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8) (K8) (Type-II keratin Kb8)
Gene: KRT8

Interactor 2: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.60	0.619

Property	Details
Experiments	31324722, 22038833
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, surface plasmon resonance
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 483 Hs			1 1480
+	Hs
		444525 K2C7_HUMAN (1-464): 4.13e-154: 448: 60.34		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		529780 KRT84_HUMAN (3-420): 6.06e-96: 303: 56.00		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		529119 KRT81_HUMAN (12-418): 1.03e-88: 282: 53.07		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		213928 KRT86_HUMAN (12-418): 3.09e-87: 277: 53.32		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		318772 K2C75_HUMAN (2-405): 3.9e-79: 258: 64.04		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		529130 K2C72_HUMAN (10-405): 1.57e-71: 237: 58.33		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		380440 K2C6B_HUMAN (56-405): 2.25e-66: 225: 70.46		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		528760 K2C6C_HUMAN (56-405): 2.63e-66: 225: 70.74		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		529332 K2C74_HUMAN (2-463): 5.35e-67: 225: 47.64		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		528450 K2C5_HUMAN (56-405): 9.54e-66: 223: 71.02		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		359458 K2C6A_HUMAN (56-405): 8.09e-65: 220: 70.74		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		529503 KRT35_HUMAN (5-402): 8.85e-64: 215: 25.31		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Mm
		514315 K2C8_MOUSE (1-483): 1.05e-59: 205: 86.74		CFTR_MOUSE (1-1468): 0: 957: 78.29
+	Hs
		528963 KRT85_HUMAN (145-469): 2.62e-09: 61.4: 12.65		CFTR_HUMAN (1-1480): 0: 1031: 100.00