HitPredict

Interactor 1: K2C8 (P05787)
Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8) (K8) (Type-II keratin Kb8)
Gene: KRT8

Interactor 2: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	36931259, 20618440
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 483 Hs			1 245
+	Mm
		910243 K22O_MOUSE (53-412): 1.17e-64: 221: 64.84		1433E_MOUSE (2-243): 1.31e-144: 406: 63.53
+	Hs
		380460 K2C6B_HUMAN (56-405): 2.25e-66: 225: 70.46		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Hs
		409044 K2C8_HUMAN (1-483): 2.44e-63: 215: 100.00		1433E_HUMAN (2-243): 1.31e-144: 406: 63.53
+	Hs
		409047 K2C8_HUMAN (1-483): 2.44e-63: 215: 100.00		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Hs
		409014 K2C8_HUMAN (1-483): 2.44e-63: 215: 100.00		1433B_HUMAN (1-242): 5.01e-139: 391: 81.82
+	Hs
		905163 KRT82_HUMAN (20-440): 2.98e-78: 255: 52.26		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33
+	Hs
		409015 K2C8_HUMAN (1-483): 2.44e-63: 215: 100.00		1433S_HUMAN (1-236): 9.86e-108: 312: 71.85
+	Hs
		409055 K2C8_HUMAN (1-483): 2.44e-63: 215: 100.00		1433F_HUMAN (2-242): 7.16e-106: 307: 71.43
+	Hs
		409042 K2C8_HUMAN (1-483): 2.44e-63: 215: 100.00		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33
+	Hs
		904944 KRT35_HUMAN (5-402): 8.85e-64: 215: 25.31		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33
+	Hs
		904437 KRT85_HUMAN (145-469): 2.62e-09: 61.4: 12.65		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33