HitPredict

Interactor 1: K2C8 (P05787)
Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8) (K8) (Type-II keratin Kb8)
Gene: KRT8

Interactor 2: EPIPL (P58107)
Epiplakin (450 kDa epidermal antigen)
Gene: EPPK1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0016327 - apicolateral plasma membrane GO:0045095 - keratin filament GO:0045109 - intermediate filament organization GO:0045111 - intermediate filament cytoskeleton
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 483 Hs			1 5088
+	Hs
		444531 K2C7_HUMAN (1-464): 4.13e-154: 448: 60.34		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Hs
		517744 K2C3_HUMAN (63-424): 5.15e-135: 405: 65.95		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Hs
		580127 K2C4_HUMAN (55-420): 5.63e-110: 337: 61.96		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Hs
		213934 KRT86_HUMAN (12-418): 3.09e-87: 277: 53.32		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Hs
		885269 K2C73_HUMAN (1-405): 2.21e-86: 277: 54.82		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Hs
		318791 K2C75_HUMAN (2-405): 3.9e-79: 258: 64.04		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Hs
		885321 KRT82_HUMAN (20-440): 2.98e-78: 255: 52.26		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Hs
		885251 K2C72_HUMAN (10-405): 1.57e-71: 237: 58.33		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Hs
		885248 K1H2_HUMAN (88-402): 1.27e-62: 212: 27.22		EPIPL_HUMAN (1-5088): 0: 4242: 100.00
+	Hs
		821662 K2C6C_HUMAN (56-405): 2.63e-66: 225: 70.74		PLEC_HUMAN (1149-4489): 2.53e-72: 275: 17.38
+	Hs
		409080 K2C8_HUMAN (1-483): 2.44e-63: 215: 100.00		PLEC_HUMAN (1149-4489): 2.53e-72: 275: 17.38
+	Hs
		531529 K2C5_HUMAN (56-405): 9.54e-66: 223: 71.02		DESP_HUMAN (2873-5087): 3.05e-30: 135: 10.82
+	Hs
		359462 K2C6A_HUMAN (56-405): 8.09e-65: 220: 70.74		DESP_HUMAN (2873-5087): 3.05e-30: 135: 10.82
+	Hs
		408995 K2C8_HUMAN (1-483): 2.44e-63: 215: 100.00		DESP_HUMAN (2873-5087): 3.05e-30: 135: 10.82
+	Hs
		234174 K2C8_HUMAN (1-483): 2.44e-63: 215: 100.00		PEPL_HUMAN (2575-3932): 2.76e-26: 122: 10.40
+	Hs
		531604 K2C5_HUMAN (56-405): 9.54e-66: 223: 71.02		NIN_HUMAN (2307-3806): 1.16e-14: 84: 9.19
+	Hs
		409163 K2C8_HUMAN (1-483): 2.44e-63: 215: 100.00		NIN_HUMAN (2307-3806): 1.16e-14: 84: 9.19
+	Hs
		408985 K2C8_HUMAN (1-483): 2.44e-63: 215: 100.00		DMD_HUMAN (1909-3327): 6.13e-09: 65.1: 11.08