HitPredict

Interactor 1: K2C8 (P05787)
Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8) (K8) (Type-II keratin Kb8)
Gene: KRT8

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	12577067, 20936779
Identification Methods	affinity chromatography technology, two hybrid, pull down, two hybrid pooling approach
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005911 - cell-cell junction and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 483 Hs			1 217
+	Hs
		444533 K2C7_HUMAN (1-464): 4.13e-154: 448: 60.34		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924469 KRT83_HUMAN (12-418): 1.84e-89: 283: 53.07		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924576 KRT81_HUMAN (12-418): 1.03e-88: 282: 53.07		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		213936 KRT86_HUMAN (12-418): 3.09e-87: 277: 53.32		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924679 K2C73_HUMAN (1-405): 2.21e-86: 277: 54.82		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Mm
		1060206 Q148Q7_MOUSE (2-405): 3.9e-80: 260: 67.33		GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54
+	Mm
		1141145 Q8BIS2_MOUSE (2-405): 2.75e-80: 260: 67.33		GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54
+	Hs
		924895 KRT82_HUMAN (20-440): 2.98e-78: 255: 52.26		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		531551 K2C5_HUMAN (56-405): 9.54e-66: 223: 71.02		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		359480 K2C6A_HUMAN (56-405): 8.09e-65: 220: 70.74		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		280786 KRT36_HUMAN (5-450): 1.51e-63: 215: 23.49		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924741 KRT35_HUMAN (5-402): 8.85e-64: 215: 25.31		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924575 K1H2_HUMAN (88-402): 1.27e-62: 212: 27.22		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924470 KRT85_HUMAN (145-469): 2.62e-09: 61.4: 12.65		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		280771 KRT36_HUMAN (5-450): 1.51e-63: 215: 23.49		HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39
+	Hs
		442865 KRT35_HUMAN (5-402): 8.85e-64: 215: 25.31		HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39
+	Mm
		403456 K2C5_MOUSE (56-405): 6.95e-64: 218: 70.74		SRC_MOUSE (161-215): 3.76e-11: 63.8: 31.58