HitPredict

Interactor 1: K2C8 (P05787)
Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8) (K8) (Type-II keratin Kb8)
Gene: KRT8

Interactor 2: CYLD (Q9NQC7)
Ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.4.19.12) (Deubiquitinating enzyme CYLD) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD)
Gene: CYLD

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	27591049, 34079125
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 483 Hs			1 956
+	Hs
		444557 K2C7_HUMAN (1-464): 4.13e-154: 448: 60.34		CYLD_HUMAN (1-956): 0: 1872: 100.00
+	Hs
		1343331 KRT84_HUMAN (3-420): 6.06e-96: 303: 56.00		CYLD_HUMAN (1-956): 0: 1872: 100.00
+	Hs
		1110348 K2C71_HUMAN (1-405): 6.81e-75: 246: 54.85		CYLD_HUMAN (1-956): 0: 1872: 100.00
+	Hs
		1062069 K2C72_HUMAN (10-405): 1.57e-71: 237: 58.33		CYLD_HUMAN (1-956): 0: 1872: 100.00
+	Hs
		380523 K2C6B_HUMAN (56-405): 2.25e-66: 225: 70.46		CYLD_HUMAN (1-956): 0: 1872: 100.00
+	Hs
		531636 K2C5_HUMAN (56-405): 9.54e-66: 223: 71.02		CYLD_HUMAN (1-956): 0: 1872: 100.00
+	Hs
		359537 K2C6A_HUMAN (56-405): 8.09e-65: 220: 70.74		CYLD_HUMAN (1-956): 0: 1872: 100.00