HitPredict

Interactor 1: CRBA1 (P05813)
Beta-crystallin A3 [Cleaved into: Beta-crystallin A3, isoform A1, Delta4 form; Beta-crystallin A3, isoform A1, Delta7 form; Beta-crystallin A3, isoform A1, Delta8 form]
Gene: CRYBA1

Interactor 2: CRBB3 (P26998)
Beta-crystallin B3 (Beta-B3 crystallin) [Cleaved into: Beta-crystallin B3, N-terminally processed]
Gene: CRYBB3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.901

Property	Details
Experiments	25416956, 32296183, unassigned1304, 17662718
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Crystall~Crystall
Common GO terms	GO:0002088 - lens development in camera-type eye GO:0005212 - structural constituent of eye lens GO:0007601 - visual perception
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 215 Hs			1 211
+	Hs
		409340 CRBA1_HUMAN (1-215): 5.32e-118: 336: 100.00		CRBB2_HUMAN (1-211): 3.4e-89: 262: 53.56
+	Hs
		645961 CRBA2_HUMAN (33-215): 2.88e-88: 259: 54.35		CRBB3_HUMAN (1-211): 6.64e-114: 325: 100.00
+	Hs
		409337 CRBA1_HUMAN (1-215): 5.32e-118: 336: 100.00		CRBA1_HUMAN (22-199): 1.97e-77: 233: 43.62
+	Hs
		645955 CRBB3_HUMAN (11-214): 1.23e-80: 241: 42.72		CRBB3_HUMAN (1-211): 6.64e-114: 325: 100.00
+	Hs
		795391 CRBA4_HUMAN (27-215): 4.52e-97: 282: 68.25		CRBB2_HUMAN (1-211): 3.4e-89: 262: 53.56
+	Hs
		795390 CRBA2_HUMAN (33-215): 2.88e-88: 259: 54.35		CRBB2_HUMAN (1-211): 3.4e-89: 262: 53.56
+	Bt
		359284 CRBB3_BOVIN (11-214): 7.34e-85: 251: 44.66		CRBB2_BOVIN (1-211): 1.6e-89: 263: 54.25
+	Hs
		863882 CRBA4_HUMAN (27-215): 4.52e-97: 282: 68.25		CRBA4_HUMAN (21-199): 1.82e-75: 227: 41.27
+	Hs
		409341 CRBA1_HUMAN (1-215): 5.32e-118: 336: 100.00		CRBB1_HUMAN (98-208): 4.6e-23: 94.6: 32.46
+	Hs
		863883 CRBA4_HUMAN (27-215): 4.52e-97: 282: 68.25		CRBB1_HUMAN (98-208): 4.6e-23: 94.6: 32.46
+	Hs
		863856 CRBA2_HUMAN (33-215): 2.88e-88: 259: 54.35		CRBB1_HUMAN (98-208): 4.6e-23: 94.6: 32.46
+	Bt
		359283 CRBB2_BOVIN (14-116): 1.34e-19: 84.7: 30.48		CRBB2_BOVIN (1-211): 1.6e-89: 263: 54.25
+	Hs
		863908 CRBB1_HUMAN (12-214): 1.36e-83: 250: 48.04		CRBB1_HUMAN (98-208): 4.6e-23: 94.6: 32.46
+	Hs
		426906 CRBB2_HUMAN (14-116): 3.83e-19: 83.5: 27.62		CRGC_HUMAN (23-105): 3.45e-17: 77.3: 34.52