HitPredict

Interactor 1: HEPS (P05981)
Serine protease hepsin (EC 3.4.21.106) (Transmembrane protease serine 1) [Cleaved into: Serine protease hepsin non-catalytic chain; Serine protease hepsin catalytic chain]
Gene: HPN

Interactor 2: NECT2 (Q92692)
Nectin-2 (Herpes virus entry mediator B) (Herpesvirus entry mediator B) (HveB) (Nectin cell adhesion molecule 2) (Poliovirus receptor-related protein 2) (CD antigen CD112)
Gene: NECTIN2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Trypsin~V-set
Common GO terms	GO:0005886 - plasma membrane GO:0005911 - cell-cell junction GO:0009986 - cell surface GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 417 Hs			1 538
+	Hs
		1269118 TMPSD_HUMAN (29-411): 1.81e-125: 376: 34.46		NECT2_HUMAN (1-538): 1.67e-89: 287: 100.00
+	Hs
		1198117 TM11B_HUMAN (153-403): 4.12e-101: 308: 40.00		NECT2_HUMAN (1-538): 1.67e-89: 287: 100.00
+	Hs
		545175 TMPS4_HUMAN (13-406): 8e-131: 385: 32.58		PVR_HUMAN (25-441): 3.32e-61: 209: 42.72
+	Hs
		177812 TMPS2_HUMAN (13-406): 5.55e-120: 359: 30.73		PVR_HUMAN (25-441): 3.32e-61: 209: 42.72
+	Hs
		1031173 TMPS4_HUMAN (13-406): 8e-131: 385: 32.58		PTK7_HUMAN (4-527): 3.59e-35: 142: 14.13
+	Hs
		1294957 TMPS4_HUMAN (13-406): 8e-131: 385: 32.58		LRIG1_HUMAN (153-427): 4.08e-34: 139: 14.14
+	Hs
		299592 TMPS4_HUMAN (13-406): 8e-131: 385: 32.58		LRIG2_HUMAN (161-392): 3.45e-32: 133: 16.19
+	Hs
		545133 TM11B_HUMAN (153-403): 4.12e-101: 308: 40.00		PVR_HUMAN (25-441): 3.32e-61: 209: 42.72
+	Hs
		177883 TMPS2_HUMAN (13-406): 5.55e-120: 359: 30.73		PTK7_HUMAN (4-527): 3.59e-35: 142: 14.13
+	Hs
		1299539 TMPS4_HUMAN (13-406): 8e-131: 385: 32.58		SIG12_HUMAN (31-354): 8.23e-22: 101: 15.07
+	Hs
		1269142 ST14_HUMAN (152-400): 2.45e-50: 183: 40.70		NECT2_HUMAN (1-538): 1.67e-89: 287: 100.00
+	Hs
		1031147 TM11B_HUMAN (153-403): 4.12e-101: 308: 40.00		PTK7_HUMAN (4-527): 3.59e-35: 142: 14.13
+	Hs
		1198133 TM11B_HUMAN (153-403): 4.12e-101: 308: 40.00		LRIG1_HUMAN (153-427): 4.08e-34: 139: 14.14
+	Hs
		299569 TM11B_HUMAN (153-403): 4.12e-101: 308: 40.00		LRIG2_HUMAN (161-392): 3.45e-32: 133: 16.19
+	Hs
		1378220 TEST_HUMAN (141-411): 4.45e-95: 289: 38.03		ROBO1_HUMAN (333-538): 1.79e-18: 91.7: 8.92