HitPredict

Interactor 1: NOT3 (P06102)
General negative regulator of transcription subunit 3
Gene: NOT3

Interactor 2: NOT5 (Q12514)
General negative regulator of transcription subunit 5
Gene: NOT5

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.921

The method score is based on:

Property	Details
Experiments	9511744, 19707589, 10490603, 37968396, 18467557
Identification Methods	coimmunoprecipitation, two hybrid, affinity chromatography technology, dihydrofolate reductase reconstruction
Interaction Type	physical association, direct interaction

The annotation score is based on:

Property	Details
Interacting Pfam domains	NOT2_3_5~NOT2_3_5
Common GO terms	GO:0000289 - nuclear-transcribed mRNA poly(A) tail shortening GO:0000290 - deadenylation-dependent decapping of nuclear-transcribed mRNA GO:0000932 - P-body GO:0005634 - nucleus GO:0005737 - cytoplasm and 3 others more... GO:0016567 - protein ubiquitination GO:0030015 - CCR4-NOT core complex GO:0032968 - positive regulation of transcription elongation by RNA polymerase II
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1	836
Sc

1	560

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024