HitPredict

Interactor 1: ESR1 (P06211)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: PRS8 (P62198)
26S proteasome regulatory subunit 8 (26S proteasome AAA-ATPase subunit RPT6) (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (Thyroid hormone receptor-interacting protein 1) (TRIP1) (p45/SUG)
Gene: Psmc5

Species: Rattus norvegicus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	11818503
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0017025 - TBP-class protein binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 600 Rn			1 406
+	Hs
		369311 ESR1_HUMAN (1-600): 0: 602: 88.17		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		369310 ESR1_HUMAN (1-600): 0: 602: 88.17		PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31
+	Hs
		369145 ESR1_HUMAN (1-600): 0: 602: 88.17		PRS6B_HUMAN (1-399): 6.4e-122: 361: 41.86
+	Hs
		369100 ESR1_HUMAN (1-600): 0: 602: 88.17		PRS7_HUMAN (84-392): 1.21e-115: 345: 56.31
+	Hs
		907111 ESR2_HUMAN (27-583): 7.73e-131: 395: 44.29		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		906889 ESR2_HUMAN (27-583): 7.73e-131: 395: 44.29		PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31
+	Hs
		587150 RXRA_HUMAN (49-556): 1.35e-124: 376: 24.95		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		798727 ESR2_HUMAN (27-583): 7.73e-131: 395: 44.29		PRS6B_HUMAN (1-399): 6.4e-122: 361: 41.86
+	Hs
		500362 RARB_HUMAN (89-583): 4.2e-114: 349: 23.49		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		730322 ESR2_HUMAN (27-583): 7.73e-131: 395: 44.29		PRS7_HUMAN (84-392): 1.21e-115: 345: 56.31
+	Hs
		906980 ERR3_HUMAN (114-552): 9.62e-109: 336: 33.56		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		907008 NR1H3_HUMAN (104-553): 1.6e-106: 329: 19.38		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		611412 NR4A1_HUMAN (53-549): 1.18e-103: 327: 24.10		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		487934 RARA_HUMAN (89-559): 4.62e-104: 324: 22.72		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		530791 RARG_HUMAN (119-579): 7.31e-102: 318: 25.33		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		907027 HNF4G_HUMAN (179-578): 2.19e-101: 315: 23.69		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		510012 ERR1_HUMAN (128-551): 1.26e-100: 313: 33.88		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		611411 NR4A1_HUMAN (53-549): 1.18e-103: 327: 24.10		PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31
+	Hs
		369327 ESR1_HUMAN (1-600): 0: 602: 88.17		PRS10_HUMAN (8-101): 2.13e-10: 64: 10.64
+	Hs
		913328 ESR2_HUMAN (27-583): 7.73e-131: 395: 44.29		PRS10_HUMAN (8-101): 2.13e-10: 64: 10.64