HitPredict

Interactor 1: INSR (P06213)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Interactor 2: PDIA4 (P13667)
Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72)
Gene: PDIA4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.50	0.489

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1382 Hs			1 645
+	Rn
		102493 INSR_RAT (1-1382): 0: 1527: 94.44		G3V6T7_RAT (25-645): 0: 550: 87.28
+	Hs
		435520 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		PDIA4_HUMAN (1-645): 0: 571: 100.00
+	Rn
		544870 INSR_RAT (1-1382): 0: 1527: 94.44		PDIA6_RAT (392-645): 4.37e-51: 185: 19.85
+	Hs
		411430 INSR_HUMAN (1-1382): 0: 1530: 100.00		DJC10_HUMAN (41-295): 2.22e-45: 174: 22.47
+	Hs
		411271 INSR_HUMAN (1-1382): 0: 1530: 100.00		PDIA1_HUMAN (4-165): 4.25e-32: 132: 27.11
+	Rn
		388065 INSR_RAT (1-1382): 0: 1527: 94.44		PDIA1_RAT (4-197): 4.14e-32: 132: 25.25
+	Hs
		411391 INSR_HUMAN (1-1382): 0: 1530: 100.00		PDIA6_HUMAN (57-283): 2.92e-31: 128: 28.51
+	Rn
		514117 INSR_RAT (1-1382): 0: 1527: 94.44		PDIA3_RAT (7-188): 1.33e-26: 116: 27.84
+	Hs
		411442 INSR_HUMAN (1-1382): 0: 1530: 100.00		TXND5_HUMAN (547-631): 1.03e-21: 100: 34.48
+	Hs
		435692 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		DJC10_HUMAN (41-295): 2.22e-45: 174: 22.47
+	Hs
		423108 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		PDIA1_HUMAN (4-165): 4.25e-32: 132: 27.11
+	Hs
		537757 INSRR_HUMAN (13-1341): 0: 1293: 51.12		DJC10_HUMAN (41-295): 2.22e-45: 174: 22.47
+	Hs
		537760 INSRR_HUMAN (13-1341): 0: 1293: 51.12		TXND5_HUMAN (547-631): 1.03e-21: 100: 34.48
+	Hs
		531732 EPHB2_HUMAN (521-1316): 3.12e-175: 551: 20.21		PDIA4_HUMAN (1-645): 0: 571: 100.00
+	Hs
		531731 EPHA8_HUMAN (644-1322): 3.66e-168: 531: 20.68		PDIA4_HUMAN (1-645): 0: 571: 100.00
+	Hs
		445818 ROS1_HUMAN (511-1377): 3.38e-158: 530: 22.63		PDIA4_HUMAN (1-645): 0: 571: 100.00
+	Hs
		383571 ERBB2_HUMAN (978-1381): 5.36e-93: 330: 25.67		PDIA4_HUMAN (1-645): 0: 571: 100.00
+	Hs
		532019 ALK_HUMAN (982-1339): 1.96e-70: 263: 40.53		PDIA4_HUMAN (1-645): 0: 571: 100.00
+	Hs
		445858 ROS1_HUMAN (511-1377): 3.38e-158: 530: 22.63		DJC10_HUMAN (41-295): 2.22e-45: 174: 22.47
+	Hs
		383876 ERBB2_HUMAN (978-1381): 5.36e-93: 330: 25.67		DJC10_HUMAN (41-295): 2.22e-45: 174: 22.47