HitPredict

Interactor 1: INSR (P06213)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Interactor 2: PLCG1 (P19174)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1)
Gene: PLCG1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.896

Property	Details
Experiments	22974441, 14568990, 11796522, 9593725
Identification Methods	unspecified method, cross-linking study, coimmunoprecipitation, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SH2~fn3, PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1382 Hs			1 1290
+	Rn
		499158 INSR_RAT (1-1382): 0: 1527: 94.44		PLCG1_RAT (1-1290): 0: 1299: 96.90
+	Hs
		580965 EPHA4_HUMAN (562-1354): 0: 565: 20.36		PLCG1_HUMAN (1-1290): 0: 1314: 100.00
+	Hs
		580937 EPHB2_HUMAN (521-1316): 3.12e-175: 551: 20.21		PLCG1_HUMAN (1-1290): 0: 1314: 100.00
+	Hs
		562635 EPHA4_HUMAN (562-1354): 0: 565: 20.36		PLCG2_HUMAN (18-1287): 0: 1128: 49.45
+	Hs
		383601 ERBB2_HUMAN (978-1381): 5.36e-93: 330: 25.67		PLCG1_HUMAN (1-1290): 0: 1314: 100.00
+	Hs
		537758 INSRR_HUMAN (13-1341): 0: 1293: 51.12		PLCD3_HUMAN (735-1214): 3.7e-87: 303: 27.27
+	Hs
		581078 ALK_HUMAN (982-1339): 1.96e-70: 263: 40.53		PLCG1_HUMAN (1-1290): 0: 1314: 100.00
+	Hs
		580940 LTK_HUMAN (1013-1291): 2e-71: 259: 44.52		PLCG1_HUMAN (1-1290): 0: 1314: 100.00
+	Hs
		581014 NTRK2_HUMAN (996-1292): 3.55e-70: 254: 43.38		PLCG1_HUMAN (1-1290): 0: 1314: 100.00
+	Hs
		384239 NTRK1_HUMAN (996-1286): 9.16e-68: 247: 42.62		PLCG1_HUMAN (1-1290): 0: 1314: 100.00
+	Mm
		546302 NTRK2_MOUSE (996-1292): 3.84e-69: 251: 43.05		PLCG1_MOUSE (1-1288): 0: 1302: 96.12
+	Hs
		581012 NTRK3_HUMAN (996-1290): 1.93e-64: 238: 39.43		PLCG1_HUMAN (1-1290): 0: 1314: 100.00
+	Rn
		499163 NTRK2_RAT (996-1292): 4.62e-69: 251: 43.05		PLCG1_RAT (1-1290): 0: 1299: 96.90
+	Mm
		1112476 NTRK1_MOUSE (996-1286): 9.52e-68: 247: 42.28		PLCG1_MOUSE (1-1288): 0: 1302: 96.12
+	Hs
		383591 ERBB2_HUMAN (978-1381): 5.36e-93: 330: 25.67		PLCG2_HUMAN (18-1287): 0: 1128: 49.45
+	Hs
		562650 NTRK3_HUMAN (996-1290): 1.93e-64: 238: 39.43		PLCG2_HUMAN (18-1287): 0: 1128: 49.45
+	Mm
		1141452 MERTK_MOUSE (835-1300): 5.74e-62: 233: 32.42		PLCG2_MOUSE (19-1287): 0: 1131: 50.12
+	Hs
		961599 ALK_HUMAN (982-1339): 1.96e-70: 263: 40.53		PLCB2_HUMAN (714-1264): 5.46e-89: 316: 21.99
+	Hs
		1083853 NTRK2_HUMAN (996-1292): 3.55e-70: 254: 43.38		PLCH1_HUMAN (847-1284): 8.88e-86: 310: 27.09
+	Mm
		546284 NTRK2_MOUSE (996-1292): 3.84e-69: 251: 43.05		PTN11_MOUSE (546-769): 4.4e-68: 243: 26.86