HitPredict

Interactor 1: INSR (P06213)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Interactor 2: AL3A2 (P51648)
Aldehyde dehydrogenase family 3 member A2 (EC 1.2.1.3) (EC 1.2.1.94) (Aldehyde dehydrogenase 10) (Fatty aldehyde dehydrogenase) (Microsomal aldehyde dehydrogenase)
Gene: ALDH3A2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0008544 - epidermis development
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1382 Hs			1 485
+	Rn
		102594 INSR_RAT (1-1382): 0: 1527: 94.44		G3V9W6_RAT (1-464): 1.97e-170: 493: 85.99
+	Hs
		435589 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		AL3A2_HUMAN (1-485): 0: 524: 100.00
+	Hs
		537728 INSRR_HUMAN (13-1341): 0: 1293: 51.12		AL3A2_HUMAN (1-485): 0: 524: 100.00
+	Hs
		848814 EPHA5_HUMAN (567-1319): 1.23e-176: 555: 20.98		AL3A2_HUMAN (1-485): 0: 524: 100.00
+	Hs
		665457 EPHA8_HUMAN (644-1322): 3.66e-168: 531: 20.68		AL3A2_HUMAN (1-485): 0: 524: 100.00
+	Hs
		445834 ROS1_HUMAN (511-1377): 3.38e-158: 530: 22.63		AL3A2_HUMAN (1-485): 0: 524: 100.00
+	Hs
		383700 ERBB2_HUMAN (978-1381): 5.36e-93: 330: 25.67		AL3A2_HUMAN (1-485): 0: 524: 100.00
+	Hs
		848999 ALK_HUMAN (982-1339): 1.96e-70: 263: 40.53		AL3A2_HUMAN (1-485): 0: 524: 100.00
+	Hs
		384344 NTRK1_HUMAN (996-1286): 9.16e-68: 247: 42.62		AL1B1_HUMAN (1-434): 0: 534: 24.55
+	Hs
		169168 MUSK_HUMAN (1017-1291): 1.24e-69: 254: 42.22		AL3A2_HUMAN (1-485): 0: 524: 100.00
+	Hs
		384085 NTRK1_HUMAN (996-1286): 9.16e-68: 247: 42.62		ALDH2_HUMAN (1-434): 0: 526: 23.44
+	Hs
		384519 NTRK1_HUMAN (996-1286): 9.16e-68: 247: 42.62		AL3A2_HUMAN (1-485): 0: 524: 100.00
+	Hs
		848856 NTRK3_HUMAN (996-1290): 1.93e-64: 238: 39.43		AL3A2_HUMAN (1-485): 0: 524: 100.00
+	Hs
		609217 FGFR3_HUMAN (1015-1287): 2.21e-62: 231: 40.78		AL3A2_HUMAN (1-485): 0: 524: 100.00
+	Hs
		674368 UFO_HUMAN (789-1294): 1.77e-61: 229: 31.09		AL3A2_HUMAN (1-485): 0: 524: 100.00
+	Hs
		601857 ERBB3_HUMAN (33-369): 1.76e-27: 123: 20.11		AL3A2_HUMAN (1-485): 0: 524: 100.00