HitPredict

Interactor 1: INSR (P06213)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Interactor 2: SNX27 (Q96L92)
Sorting nexin-27
Gene: SNX27

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	23382219
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PDZ~fn3
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1382 Hs			1 541
+	Rn
		102558 INSR_RAT (1-1382): 0: 1527: 94.44		G3V8U4_RAT (1-530): 0: 598: 97.93
+	Hs
		411389 INSR_HUMAN (1-1382): 0: 1530: 100.00		SNX17_HUMAN (162-535): 9.12e-108: 331: 25.31
+	Hs
		385360 NTRK1_HUMAN (996-1286): 9.16e-68: 247: 42.62		SNX27_HUMAN (1-541): 0: 625: 100.00
+	Hs
		872718 EPHA4_HUMAN (562-1354): 0: 565: 20.36		LIN7C_HUMAN (35-136): 1.5e-27: 111: 34.95
+	Hs
		153901 EPHB1_HUMAN (571-1318): 0: 569: 21.86		NHRF1_HUMAN (12-209): 7.91e-23: 101: 22.89
+	Hs
		872496 EPHA5_HUMAN (567-1319): 1.23e-176: 555: 20.98		LIN7C_HUMAN (35-136): 1.5e-27: 111: 34.95
+	Hs
		665667 EPHB2_HUMAN (521-1316): 3.12e-175: 551: 20.21		LIN7C_HUMAN (35-136): 1.5e-27: 111: 34.95
+	Hs
		1072612 EPHA7_HUMAN (562-1356): 4.76e-172: 541: 19.48		LIN7C_HUMAN (35-136): 1.5e-27: 111: 34.95
+	Hs
		872669 EPHA4_HUMAN (562-1354): 0: 565: 20.36		MAGI2_HUMAN (45-372): 3.17e-16: 84.6: 14.79
+	Hs
		153921 EPHA7_HUMAN (562-1356): 4.76e-172: 541: 19.48		NHRF1_HUMAN (12-209): 7.91e-23: 101: 22.89
+	Hs
		445876 ROS1_HUMAN (511-1377): 3.38e-158: 530: 22.63		SHAN3_HUMAN (44-148): 1.57e-21: 101: 37.14
+	Hs
		384868 NTRK1_HUMAN (996-1286): 9.16e-68: 247: 42.62		SNX17_HUMAN (162-535): 9.12e-108: 331: 25.31
+	Hs
		153855 ERBB2_HUMAN (978-1381): 5.36e-93: 330: 25.67		NHRF1_HUMAN (12-209): 7.91e-23: 101: 22.89
+	Hs
		169214 MUSK_HUMAN (1017-1291): 1.24e-69: 254: 42.22		PZRN3_HUMAN (21-281): 3.18e-33: 136: 17.10
+	Hs
		153877 LTK_HUMAN (1013-1291): 2e-71: 259: 44.52		NHRF1_HUMAN (12-209): 7.91e-23: 101: 22.89
+	Hs
		1081620 NTRK3_HUMAN (996-1290): 1.93e-64: 238: 39.43		LIN7C_HUMAN (35-136): 1.5e-27: 111: 34.95
+	Hs
		153856 NTRK1_HUMAN (996-1286): 9.16e-68: 247: 42.62		NHRF1_HUMAN (12-209): 7.91e-23: 101: 22.89
+	Hs
		153881 UFO_HUMAN (789-1294): 1.77e-61: 229: 31.09		NHRF1_HUMAN (12-209): 7.91e-23: 101: 22.89
+	Hs
		384706 NTRK1_HUMAN (996-1286): 9.16e-68: 247: 42.62		ZO1_HUMAN (4-254): 7.48e-12: 70.3: 13.97
+	Hs
		674404 UFO_HUMAN (789-1294): 1.77e-61: 229: 31.09		ZO1_HUMAN (4-254): 7.48e-12: 70.3: 13.97