HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: PTPRC (P08575)
Receptor-type tyrosine-protein phosphatase C (EC 3.1.3.48) (Leukocyte common antigen) (L-CA) (T200) (CD antigen CD45)
Gene: PTPRC

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.980

The method score is based on:

Property Details
Experiments 14625311, 9533446, 8473339, 8576115, 15085197, 24463463, 10369126, 7507203, 19167335
Identification Methods pull down, enzymatic study, affinity chromatography technology, protein phosphatase assay, phosphatase assay, protein kinase assay, anti bait coimmunoprecipitation
Interaction Type direct interaction, physical association, association, dephosphorylation reaction, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains PK_Tyr_Ser-Thr~fn3, PK_Tyr_Ser-Thr~Y_phosphatase, SH2~fn3, SH2~Y_phosphatase
Common GO terms GO:0005102 - signaling receptor binding
GO:0005886 - plasma membrane
GO:0019901 - protein kinase binding
GO:0030217 - T cell differentiation
GO:0045121 - membrane raft
and 4 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Last updated: 15 Jul 2024