HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: FCG3A (P08637)
Low affinity immunoglobulin gamma Fc region receptor III-A (IgG Fc receptor III-A) (CD16-II) (CD16a antigen) (Fc-gamma RIII-alpha) (Fc-gamma RIII) (Fc-gamma RIIIa) (FcRIII) (FcRIIIa) (FcgammaRIIIA) (FcR-10) (IgG Fc receptor III-2) (CD antigen CD16a)
Gene: FCGR3A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	8405050
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0038094 - Fc-gamma receptor signaling pathway GO:0070062 - extracellular exosome
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 509 Hs			1 254
+	Hs
		442771 HCK_HUMAN (1-509): 0: 602: 65.04		FCGR1_HUMAN (27-234): 3.56e-22: 95.8: 15.39
+	Hs
		523211 SRC_HUMAN (20-507): 0: 586: 55.00		TUTLB_HUMAN (13-209): 2.67e-27: 111: 14.88
+	Hs
		434081 LYN_HUMAN (1-509): 0: 582: 62.72		TUTLB_HUMAN (13-209): 2.67e-27: 111: 14.88
+	Hs
		433507 YES_HUMAN (26-507): 0: 581: 58.06		TUTLB_HUMAN (13-209): 2.67e-27: 111: 14.88
+	Mm
		639452 LYN_MOUSE (1-509): 0: 585: 62.33		FCRL5_MOUSE (7-252): 3.39e-24: 102: 15.04
+	Hs
		433947 LYN_HUMAN (1-509): 0: 582: 62.72		KIRR1_HUMAN (1-225): 6.46e-24: 102: 14.02
+	Mm
		435878 HCK_MOUSE (1-509): 0: 590: 63.99		FCGR1_MOUSE (15-241): 1.04e-20: 92: 15.48
+	Hs
		434111 LYN_HUMAN (1-509): 0: 582: 62.72		ROBO1_HUMAN (103-252): 3.73e-21: 94.3: 7.61
+	Hs
		519400 SRC_HUMAN (20-507): 0: 586: 55.00		FCERA_HUMAN (102-248): 1.33e-16: 78.5: 16.46
+	Hs
		412048 FYN_HUMAN (30-507): 0: 586: 59.01		FCG2C_HUMAN (98-248): 1.33e-13: 71.2: 17.68
+	Hs
		522812 SRC_HUMAN (20-507): 0: 586: 55.00		FCG2C_HUMAN (98-248): 1.33e-13: 71.2: 17.68
+	Hs
		412047 FYN_HUMAN (30-507): 0: 586: 59.01		FCG2B_HUMAN (98-248): 1.7e-13: 70.8: 17.68
+	Hs
		522811 SRC_HUMAN (20-507): 0: 586: 55.00		FCG2B_HUMAN (98-248): 1.7e-13: 70.8: 17.68
+	Hs
		434019 LYN_HUMAN (1-509): 0: 582: 62.72		ROBO2_HUMAN (11-100): 1.16e-13: 72.3: 15.69
+	Hs
		433610 LYN_HUMAN (1-509): 0: 582: 62.72		FCG2B_HUMAN (98-248): 1.7e-13: 70.8: 17.68
+	Dm
		219802 ABL_DROME (43-502): 3.42e-171: 525: 42.34		O44924_DROME (12-211): 9.95e-33: 127: 14.72
+	Hs
		433545 LYN_HUMAN (1-509): 0: 582: 62.72		FCG2A_HUMAN (109-248): 5.3e-13: 69.2: 18.67
+	Hs
		433569 LYN_HUMAN (1-509): 0: 582: 62.72		CD22_HUMAN (73-253): 3.13e-11: 65: 14.02
+	Hs
		789014 TEC_HUMAN (7-503): 2.17e-169: 494: 32.56		TUTLB_HUMAN (13-209): 2.67e-27: 111: 14.88