HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.747

Property	Details
Experiments	8900205, 11904433, 34831026, 8626543, 16107303, 7721825, 8621719
Identification Methods	pull down, affinity chromatography technology, enzymatic study, coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001784 - phosphotyrosine residue binding GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0045121 - membrane raft
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 509 Hs			1 906
+	Mm
		411917 LCK_MOUSE (1-509): 0: 657: 96.86		CBL_MOUSE (1-906): 0: 888: 91.59
+	Hs
		442780 HCK_HUMAN (1-509): 0: 602: 65.04		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		412013 FYN_HUMAN (30-507): 0: 586: 59.01		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		522778 SRC_HUMAN (20-507): 0: 586: 55.00		CBL_HUMAN (1-906): 0: 917: 100.00
+	Mm
		536206 FGR_MOUSE (1-507): 0: 591: 53.19		CBL_MOUSE (1-906): 0: 888: 91.59
+	Mm
		435877 HCK_MOUSE (1-509): 0: 590: 63.99		CBL_MOUSE (1-906): 0: 888: 91.59
+	Mm
		610554 FYN_MOUSE (30-507): 0: 586: 58.80		CBL_MOUSE (1-906): 0: 888: 91.59
+	Hs
		411703 LCK_HUMAN (1-509): 0: 661: 100.00		CBLB_HUMAN (23-901): 0: 793: 46.65
+	Mm
		411924 LCK_MOUSE (1-509): 0: 657: 96.86		CBLB_MOUSE (23-901): 0: 791: 45.98
+	Rn
		88775 LYN_RAT (1-509): 0: 590: 62.33		D3ZV15_RAT (1-883): 0: 833: 89.00
+	Hs
		412170 FYN_HUMAN (30-507): 0: 586: 59.01		CBLB_HUMAN (23-901): 0: 793: 46.65
+	Hs
		522956 SRC_HUMAN (20-507): 0: 586: 55.00		CBLB_HUMAN (23-901): 0: 793: 46.65
+	Rn
		1144046 FYN_RAT (30-507): 0: 585: 58.80		CBLB_RAT (23-901): 0: 792: 46.98
+	Hs
		412405 FYN_HUMAN (30-507): 0: 586: 59.01		CBLC_HUMAN (42-504): 0: 620: 42.07
+	Hs
		523198 SRC_HUMAN (20-507): 0: 586: 55.00		CBLC_HUMAN (42-504): 0: 620: 42.07
+	Hs
		203198 LCK_HUMAN (1-509): 0: 661: 100.00		SYNJ1_HUMAN (542-897): 2.72e-14: 79.6: 10.22
+	Hs
		411582 LCK_HUMAN (1-509): 0: 661: 100.00		MUC1_HUMAN (449-906): 3.82e-14: 79.2: 10.58
+	Hs
		411823 LCK_HUMAN (1-509): 0: 661: 100.00		ASPP1_HUMAN (445-844): 1.47e-10: 67.3: 10.25
+	Hs
		412362 FYN_HUMAN (30-507): 0: 586: 59.01		MAGE1_HUMAN (527-872): 1.47e-14: 80.4: 12.36
+	Hs
		522749 SRC_HUMAN (20-507): 0: 586: 55.00		MUC1_HUMAN (449-906): 3.82e-14: 79.2: 10.58