HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: TNR6 (P25445)
Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95)
Gene: FAS

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.602

Property	Details
Experiments	8864141, 20696918
Identification Methods	pull down, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0045121 - membrane raft GO:0070062 - extracellular exosome
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 509 Hs			1 335
+	Hs
		412024 FYN_HUMAN (30-507): 0: 586: 59.01		TNR6_HUMAN (1-335): 2.61e-113: 333: 100.00
+	Hs
		522788 SRC_HUMAN (20-507): 0: 586: 55.00		TNR6_HUMAN (1-335): 2.61e-113: 333: 100.00
+	Hs
		433256 YES_HUMAN (26-507): 0: 581: 58.06		TNR6_HUMAN (1-335): 2.61e-113: 333: 100.00
+	Hs
		632254 BTK_HUMAN (7-505): 1.49e-167: 490: 33.27		TNR6_HUMAN (1-335): 2.61e-113: 333: 100.00
+	Hs
		522761 SRC_HUMAN (20-507): 0: 586: 55.00		TNR1A_HUMAN (22-202): 6.36e-42: 153: 20.65
+	Mm
		192581 LYN_MOUSE (1-509): 0: 585: 62.33		TNR11_MOUSE (13-239): 2.89e-38: 145: 17.90
+	Mm
		411916 LCK_MOUSE (1-509): 0: 657: 96.86		TNR9_MOUSE (60-247): 1.37e-12: 68.8: 13.83
+	Hs
		154294 FYN_HUMAN (30-507): 0: 586: 59.01		TR10B_HUMAN (42-216): 2.84e-31: 123: 21.91
+	Mm
		591446 FYN_MOUSE (30-507): 0: 586: 58.80		TNR9_MOUSE (60-247): 1.37e-12: 68.8: 13.83
+	Mm
		648950 BTK_MOUSE (7-505): 6.84e-168: 491: 32.89		TNR5_MOUSE (31-224): 2.34e-37: 136: 20.92