HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	19010391
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	14-3-3~PK_Tyr_Ser-Thr
Common GO terms	GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 509 Hs			1 245
+	Hs
		411661 LCK_HUMAN (1-509): 0: 661: 100.00		1433E_HUMAN (2-243): 1.31e-144: 406: 63.53
+	Hs
		411666 LCK_HUMAN (1-509): 0: 661: 100.00		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Hs
		411616 LCK_HUMAN (1-509): 0: 661: 100.00		1433S_HUMAN (1-236): 9.86e-108: 312: 71.85
+	Hs
		909481 ITK_HUMAN (7-500): 1.08e-177: 515: 33.33		1433E_HUMAN (2-243): 1.31e-144: 406: 63.53
+	Hs
		337416 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		1433E_HUMAN (2-243): 1.31e-144: 406: 63.53
+	Hs
		337355 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		1433T_HUMAN (1-245): 9.47e-142: 398: 100.00
+	Hs
		337420 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Hs
		789053 ABL2_HUMAN (57-502): 3.29e-166: 502: 42.95		1433E_HUMAN (2-243): 1.31e-144: 406: 63.53
+	Hs
		337366 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		1433B_HUMAN (1-242): 5.01e-139: 391: 81.82
+	Hs
		646706 ABL2_HUMAN (57-502): 3.29e-166: 502: 42.95		1433T_HUMAN (1-245): 9.47e-142: 398: 100.00
+	Hs
		789056 ABL2_HUMAN (57-502): 3.29e-166: 502: 42.95		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Hs
		683185 ABL2_HUMAN (57-502): 3.29e-166: 502: 42.95		1433B_HUMAN (1-242): 5.01e-139: 391: 81.82
+	Hs
		683994 ITK_HUMAN (7-500): 1.08e-177: 515: 33.33		1433S_HUMAN (1-236): 9.86e-108: 312: 71.85
+	Hs
		337367 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		1433S_HUMAN (1-236): 9.86e-108: 312: 71.85
+	Hs
		337436 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		1433F_HUMAN (2-242): 7.16e-106: 307: 71.43
+	Hs
		337415 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33
+	Hs
		683884 ABL2_HUMAN (57-502): 3.29e-166: 502: 42.95		1433S_HUMAN (1-236): 9.86e-108: 312: 71.85
+	Hs
		789060 ABL2_HUMAN (57-502): 3.29e-166: 502: 42.95		1433F_HUMAN (2-242): 7.16e-106: 307: 71.43
+	Hs
		789052 ABL2_HUMAN (57-502): 3.29e-166: 502: 42.95		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33
+	Hs
		683983 BTK_HUMAN (7-505): 1.49e-167: 490: 33.27		1433S_HUMAN (1-236): 9.86e-108: 312: 71.85