HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	14-3-3~PK_Tyr_Ser-Thr
Common GO terms	GO:0005829 - cytosol GO:0006468 - protein phosphorylation GO:0019901 - protein kinase binding GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 509 Hs			1 245
+	Hs
		411661 LCK_HUMAN (1-509): 0: 661: 100.00		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18
+	Hs
		411605 LCK_HUMAN (1-509): 0: 661: 100.00		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Hs
		411616 LCK_HUMAN (1-509): 0: 661: 100.00		1433S_HUMAN (1-237): 8.27e-104: 302: 71.97
+	Hs
		337420 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00
+	Hs
		909481 ITK_HUMAN (7-500): 1.08e-177: 515: 33.33		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18
+	Hs
		337416 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18
+	Hs
		337355 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Hs
		789056 ABL2_HUMAN (57-502): 3.29e-166: 502: 42.95		1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00
+	Hs
		337366 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		1433B_HUMAN (1-242): 9.01e-140: 393: 87.60
+	Hs
		789053 ABL2_HUMAN (57-502): 3.29e-166: 502: 42.95		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18
+	Hs
		646706 ABL2_HUMAN (57-502): 3.29e-166: 502: 42.95		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Hs
		683185 ABL2_HUMAN (57-502): 3.29e-166: 502: 42.95		1433B_HUMAN (1-242): 9.01e-140: 393: 87.60
+	Hs
		337415 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		337436 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		1433F_HUMAN (2-240): 1.26e-107: 312: 74.49
+	Hs
		683994 ITK_HUMAN (7-500): 1.08e-177: 515: 33.33		1433S_HUMAN (1-237): 8.27e-104: 302: 71.97
+	Hs
		789052 ABL2_HUMAN (57-502): 3.29e-166: 502: 42.95		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		337367 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		1433S_HUMAN (1-237): 8.27e-104: 302: 71.97
+	Hs
		789060 ABL2_HUMAN (57-502): 3.29e-166: 502: 42.95		1433F_HUMAN (2-240): 1.26e-107: 312: 74.49
+	Hs
		683884 ABL2_HUMAN (57-502): 3.29e-166: 502: 42.95		1433S_HUMAN (1-237): 8.27e-104: 302: 71.97
+	Hs
		683983 BTK_HUMAN (7-505): 1.49e-167: 490: 33.27		1433S_HUMAN (1-237): 8.27e-104: 302: 71.97