HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: SOS1 (Q07889)
Son of sevenless homolog 1 (SOS-1)
Gene: SOS1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.27	1.00	0.527

Property	Details
Experiments	16274251
Identification Methods	unspecified method
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PH~SH3_1, RhoGEF~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0050853 - B cell receptor signaling pathway GO:0050900 - leukocyte migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 509 Hs			1 1333
+	Hs
		442816 HCK_HUMAN (1-509): 0: 602: 65.04		SOS1_HUMAN (1-1333): 0: 991: 100.00
+	Hs
		412150 FYN_HUMAN (30-507): 0: 586: 59.01		SOS1_HUMAN (1-1333): 0: 991: 100.00
+	Hs
		522934 SRC_HUMAN (20-507): 0: 586: 55.00		SOS1_HUMAN (1-1333): 0: 991: 100.00
+	Hs
		337446 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		SOS1_HUMAN (1-1333): 0: 991: 100.00
+	Hs
		412151 FYN_HUMAN (30-507): 0: 586: 59.01		SOS2_HUMAN (1-1332): 0: 855: 68.03
+	Hs
		522935 SRC_HUMAN (20-507): 0: 586: 55.00		SOS2_HUMAN (1-1332): 0: 855: 68.03
+	Hs
		337447 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		SOS2_HUMAN (1-1332): 0: 855: 68.03
+	Dm
		644374 SRC42_DROME (28-507): 0: 562: 51.11		SOS_DROME (8-1305): 0: 692: 42.34
+	Hs
		411580 LCK_HUMAN (1-509): 0: 661: 100.00		VAV_HUMAN (134-691): 1.71e-76: 274: 14.41
+	Hs
		522974 SRC_HUMAN (20-507): 0: 586: 55.00		RGRF1_HUMAN (10-651): 1.6e-97: 343: 14.18
+	Hs
		442826 HCK_HUMAN (1-509): 0: 602: 65.04		RPGF1_HUMAN (571-1032): 8.27e-91: 320: 23.63
+	Hs
		412185 FYN_HUMAN (30-507): 0: 586: 59.01		RPGF1_HUMAN (571-1032): 8.27e-91: 320: 23.63
+	Hs
		522972 SRC_HUMAN (20-507): 0: 586: 55.00		RPGF1_HUMAN (571-1032): 8.27e-91: 320: 23.63
+	Hs
		224698 LCK_HUMAN (1-509): 0: 661: 100.00		KALRN_HUMAN (8-625): 2.16e-64: 244: 12.85
+	Hs
		279830 LCK_HUMAN (1-509): 0: 661: 100.00		TRIO_HUMAN (101-691): 1.18e-59: 229: 12.83
+	Hs
		411981 FYN_HUMAN (30-507): 0: 586: 59.01		VAV_HUMAN (134-691): 1.71e-76: 274: 14.41
+	Hs
		337471 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		RPGF1_HUMAN (571-1032): 8.27e-91: 320: 23.63
+	Hs
		224699 FYN_HUMAN (30-507): 0: 586: 59.01		KALRN_HUMAN (8-625): 2.16e-64: 244: 12.85
+	Hs
		279832 LYN_HUMAN (1-509): 0: 582: 62.72		TRIO_HUMAN (101-691): 1.18e-59: 229: 12.83
+	Hs
		337333 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		VAV_HUMAN (134-691): 1.71e-76: 274: 14.41