HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: FLII (Q13045)
Protein flightless-1 homolog
Gene: FLII

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	LRR_4~PK_Tyr_Ser-Thr, LRR_8~PK_Tyr_Ser-Thr, LRR_8~SH2, LRR_4~SH3_1
Common GO terms	GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 509 Hs			1 1269
+	Hs
		413814 SRC_HUMAN (20-507): 0: 586: 55.00		GELS_HUMAN (481-1269): 0: 798: 24.85
+	Hs
		413803 YES_HUMAN (26-507): 0: 581: 58.06		GELS_HUMAN (481-1269): 0: 798: 24.85
+	Hs
		448963 SRC_HUMAN (20-507): 0: 586: 55.00		VILI_HUMAN (892-1269): 3.51e-57: 215: 15.42
+	Hs
		411826 LCK_HUMAN (1-509): 0: 661: 100.00		ERBIN_HUMAN (10-376): 1.85e-23: 110: 28.27
+	Hs
		433956 LYN_HUMAN (1-509): 0: 582: 62.72		ERBIN_HUMAN (10-376): 1.85e-23: 110: 28.27
+	Hs
		313728 LYN_HUMAN (1-509): 0: 582: 62.72		SVIL_HUMAN (1056-1267): 1.52e-21: 104: 17.69
+	Hs
		433978 LYN_HUMAN (1-509): 0: 582: 62.72		LRRC1_HUMAN (116-379): 5.94e-20: 97.1: 29.76