HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: RHOH (Q15669)
Rho-related GTP-binding protein RhoH (GTP-binding protein TTF) (Translocation three four protein)
Gene: RHOH

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	27574848
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001772 - immunological synapse GO:0005886 - plasma membrane GO:0019901 - protein kinase binding GO:0030217 - T cell differentiation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 509 Hs			1 191
+	Hs
		412207 FYN_HUMAN (30-507): 0: 586: 59.01		RHOH_HUMAN (1-191): 2.74e-95: 276: 100.00
+	Hs
		433777 LYN_HUMAN (1-509): 0: 582: 62.72		RHOH_HUMAN (1-191): 2.74e-95: 276: 100.00
+	Hs
		411948 FYN_HUMAN (30-507): 0: 586: 59.01		RHOC_HUMAN (6-185): 6.48e-85: 250: 42.25
+	Hs
		412120 FYN_HUMAN (30-507): 0: 586: 59.01		RHOB_HUMAN (6-191): 6.57e-85: 250: 40.93
+	Hs
		522885 SRC_HUMAN (20-507): 0: 586: 55.00		RHOB_HUMAN (6-191): 6.57e-85: 250: 40.93
+	Hs
		433524 LYN_HUMAN (1-509): 0: 582: 62.72		RHOC_HUMAN (6-185): 6.48e-85: 250: 42.25
+	Hs
		433681 LYN_HUMAN (1-509): 0: 582: 62.72		RHOB_HUMAN (6-191): 6.57e-85: 250: 40.93
+	Hs
		433217 YES_HUMAN (26-507): 0: 581: 58.06		RHOC_HUMAN (6-185): 6.48e-85: 250: 42.25
+	Hs
		412123 FYN_HUMAN (30-507): 0: 586: 59.01		RAC1_HUMAN (2-191): 2.63e-75: 226: 39.09
+	Hs
		522888 SRC_HUMAN (20-507): 0: 586: 55.00		RAC1_HUMAN (2-191): 2.63e-75: 226: 39.09
+	Hs
		433685 LYN_HUMAN (1-509): 0: 582: 62.72		RAC1_HUMAN (2-191): 2.63e-75: 226: 39.09
+	Hs
		412113 FYN_HUMAN (30-507): 0: 586: 59.01		CDC42_HUMAN (2-181): 1.52e-73: 221: 42.25
+	Hs
		411980 FYN_HUMAN (30-507): 0: 586: 59.01		RAC2_HUMAN (2-191): 1.96e-72: 218: 38.07
+	Hs
		433565 LYN_HUMAN (1-509): 0: 582: 62.72		RHOQ_HUMAN (5-190): 8.15e-74: 222: 39.49
+	Hs
		433673 LYN_HUMAN (1-509): 0: 582: 62.72		CDC42_HUMAN (2-181): 1.52e-73: 221: 42.25
+	Hs
		412115 FYN_HUMAN (30-507): 0: 586: 59.01		RHOA_HUMAN (6-191): 8.9e-71: 214: 39.38
+	Hs
		433556 LYN_HUMAN (1-509): 0: 582: 62.72		RAC2_HUMAN (2-191): 1.96e-72: 218: 38.07
+	Hs
		433671 LYN_HUMAN (1-509): 0: 582: 62.72		RAC3_HUMAN (2-171): 3.86e-72: 218: 41.81
+	Hs
		433239 YES_HUMAN (26-507): 0: 581: 58.06		RAC2_HUMAN (2-191): 1.96e-72: 218: 38.07
+	Hs
		433677 LYN_HUMAN (1-509): 0: 582: 62.72		RHOA_HUMAN (6-191): 8.9e-71: 214: 39.38