HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: Q4LE69 (Q4LE69)
1-phosphatidylinositol 4-kinase (EC 2.7.1.67)
Gene: PIK4CA

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	8246987, 34079125
Identification Methods	pull down, proximity labelling technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PI3_PI4_kinase~SH2, PI3Ka~SH2
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 509 Hs			1 2121
+	Hs
		433799 LYN_HUMAN (1-509): 0: 582: 62.72		Q4LE69_HUMAN (1-2121): 0: 2752: 100.00
+	Hs
		411630 LCK_HUMAN (1-509): 0: 661: 100.00		PK3CA_HUMAN (1461-2117): 1.72e-151: 500: 21.77
+	Hs
		411640 LCK_HUMAN (1-509): 0: 661: 100.00		PK3CG_HUMAN (1522-2119): 7.16e-133: 448: 19.56
+	Mm
		403443 SRC_MOUSE (28-507): 0: 583: 57.05		P3C2A_MOUSE (1411-2120): 1.78e-152: 519: 17.98
+	Mm
		411931 LCK_MOUSE (1-509): 0: 657: 96.86		PK3CG_MOUSE (1522-2119): 4.65e-131: 443: 19.87
+	Hs
		522837 SRC_HUMAN (20-507): 0: 586: 55.00		PK3CA_HUMAN (1461-2117): 1.72e-151: 500: 21.77
+	Hs
		433644 LYN_HUMAN (1-509): 0: 582: 62.72		PK3CG_HUMAN (1522-2119): 7.16e-133: 448: 19.56